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CASP8 — TFAP2A
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TFAP2A
→
CASP8
(decreases)
Nyormoi et al., Mol Cell Biol 2001*
Evidence: Treatment of cells with inhibitors of Caspase 2 (zVDAVADfmk) and Caspase 8 (zLETDfmk), moderately prevented the downregulation of AP2 alpha expression and also had only a moderate effect on apoptosis.
Text-mined interactions from Literome
Nyormoi et al., Mol Cell Biol 2001
(Breast Neoplasms) :
Cells transfected with green fluorescent protein tagged mutant AP-2alpha are resistant to TNF-alpha induced apoptosis, further demonstrating the link between
caspase mediated cleavage of
AP-2alpha and apoptosis
Gan et al., Acta Pharmacol Sin 2008
:
Furthermore, overexpressing
AP-2alpha increased the expression and activity of
caspase-3 , whereas antisense AP-2alpha in part abolished the increased effects of doxazosin on caspase-3 expression and activity