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IFNG — TNFSF4
Text-mined interactions from Literome
Grosenbach et al., Cell Immunol 2003
:
These studies demonstrate that ( a) OX40L plays a role in sustaining the long-term proliferation of CD8 ( + ) T cells in addition to the known effect on CD4 ( + ) T cells following activation, ( b )
OX40L enhances the production of Th1 cytokines ( IL-2,
IFN-gamma , and TNF-alpha ) from both CD4 ( + ) and CD8 ( + ) while no change in IL-4 expression was observed, and ( c ) the anti-apoptotic effect of OX40L on T cells is likely the result of sustained expression of anti-apoptotic genes while genes involved in apoptosis are inhibited
Zingoni et al., J Immunol 2004
:
CD16 activated NK cells costimulate TCR induced proliferation, and
IFN-gamma produced by autologous CD4+ T cells and this process is
dependent upon expression of
OX40 ligand and B7 by the activated NK cells
Liu et al., J Clin Invest 2008
(Melanoma, Experimental) :
NK cell recruitment was mediated by CCR5 via chemokines secreted by pDCs, and optimal
IFN-gamma production by NK cells was
mediated by
OX40L expressed by pDCs
Lee et al., Immunology 2008
:
We found that de novo expression or overexpression of
OX40L , 4-1BBL and IL-12p70 on activated B cells synergistically
enhanced proliferation as well as IL-2 and
interferon-gamma production by CD8+ T cells
Li et al., Cell Immunol 2008
:
In agreement with prior reports,
OX40L signaling through CD134
increased IFNgamma and IL-4, both of which are reported to inhibit the production of IL-17
Krimmer et al., Allergy 2009
(Asthma) :
The aim of this study was to examine the
effect of tumour necrosis factor-alpha (TNF-alpha) and
interferon-gamma (IFN-gamma) on ASM CD40 and
OX40L expression ... In contrast,
IFN-gamma reduced TNF-alpha induced
OX40L expression to a similar extent in both cell types ...
IFN-gamma may
regulate ASM pro-inflammatory actions by differentially modulating ASM CD40 and
OX40L expression