Gene interactions and pathways from curated databases and text-mining

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JUN — PPARA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Delerive et al., Circ Res 1999 (Arteriosclerosis) : Furthermore, electrophoretic mobility shift assays demonstrated that PPAR activators reduce the thrombin stimulated binding activity of bovine aortic endothelial cell nuclear extracts as well as c-Jun binding to an activator protein-1 consensus site
Delerive et al., J Biol Chem 1999 (Phlebitis) : Furthermore, activation of PPARalpha represses both c-Jun- and p65 induced transcription of the human IL-6 promoter ... Transcriptional interference between PPARalpha and both c-Jun and p65 occurs reciprocally, since c-Jun and p65 also inhibit PPARalpha mediated activation of a PPAR response element-driven promoter
Grau et al., Biochem J 2006 (Colorectal Neoplasms) : First, PPARalpha activation impaired AP-1 binding to a consensus DNA sequence ... Secondly, PPARalpha ligands inhibited c-Jun transactivating activity
Ban et al., Mol Cell Biochem 2012 : Furthermore, downregulation of PPAR? by arginine involved phosphorylation of c-Jun that occurred before to changes in PPAR? transcriptional activity ... Silencing of c-Jun increased PPAR? beyond that of nonsilenced cells and was not mitigated by arginine
Ungaro et al., J Biol Chem 2012 : These results indicate that PPAR? regulates ped/pea-15 transcription by inhibiting c-JUN binding at the ped/pea-15 promoter
Hou et al., Eur J Pharmacol 2013 : To investigate the mechanisms involved, we found that PPAR-? activation by rosiglitazone inhibited the formation of c-fos/c-jun heterodimers and expression of activator protein 1 induced by ANG II and thus inhibited transcription of the downstream genes involved in CFs proliferation and differentiation