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JUN — PPARA
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
O/- complex ()
→
Complex of JUN-PPARA
(decreases, JUN/PPARA Activity)
Cabrero et al., Curr Drug Targets Inflamm Allergy 2002*
Evidence: PPARa activation reduces AP-1 DNA-binding activity by physically interacting with c-Jun [28,37].
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OpenBEL Selventa BEL large corpus:
PPARA
→
JUN
(decreases, JUN Activity, PPARA Activity)
Delerive et al., J Biol Chem 1999*
Evidence: Transcriptional interference between PPARalpha and both c-Jun and p65 occurs reciprocally, since c-Jun and p65 also inhibit PPARalpha-mediated activation of a PPAR response element-driven promoter.
-
OpenBEL Selventa BEL large corpus:
JUN
→
PPARA
(decreases, PPARA Activity, JUN Activity)
Delerive et al., J Biol Chem 1999*
Evidence: Transcriptional interference between PPARalpha and both c-Jun and p65 occurs reciprocally, since c-Jun and p65 also inhibit PPARalpha-mediated activation of a PPAR response element-driven promoter.
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BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1)
→
0005667 (JUN/RELA/SP1/STAT5A/STAT5B)
(modification, collaborate)
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BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1)
→
PPAR-alpha (PPARA)
(modification, collaborate)
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BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
0005667 (JUN/RELA/SP1/STAT5A/STAT5B)
→
PPAR-alpha (PPARA)
(modification, collaborate)
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BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1)
→
PPAR-alpha/Nuclear receptors complex (PPARA-NR0B2_NR2F1_RXRA)
(transcription, inhibits)
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BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1)
→
Non-PPRE-Regulated proteins (NOS2A/TNF/MYC/FAT/COX2/NFKBIA)
(transcription, inhibits)
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BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1)
→
PPRE-Regulated proteins (LPL/APOA1/CPT1A/HSD17B4/APOA2/ME1/ACOX1/NR1H3/FABP1/EHHADH)
(transcription, inhibits)
-
BioCarta mechanism of gene regulation by peroxisome proliferators via ppara:
PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1)
→
PPAR-alpha/PPAR ligands/RXR/Co-Activators complex (PPARA-RXRA-CITED2_NCOA1_PPARGC1A_CREBBP_NRIP1_EP300_PPARBP_SRA1)
(transcription, inhibits)
Text-mined interactions from Literome
Delerive et al., Circ Res 1999
(Arteriosclerosis) :
Furthermore, electrophoretic mobility shift assays demonstrated that
PPAR activators
reduce the thrombin stimulated binding activity of bovine aortic endothelial cell nuclear extracts as well as
c-Jun binding to an activator protein-1 consensus site
Delerive et al., J Biol Chem 1999
(Phlebitis) :
Furthermore, activation of
PPARalpha represses both
c-Jun- and p65 induced transcription of the human IL-6 promoter ... Transcriptional interference between PPARalpha and both c-Jun and p65 occurs reciprocally, since
c-Jun and p65 also
inhibit PPARalpha mediated activation of a
PPAR response element-driven promoter
Grau et al., Biochem J 2006
(Colorectal Neoplasms) :
First,
PPARalpha activation
impaired AP-1 binding to a consensus DNA sequence ... Secondly,
PPARalpha ligands
inhibited c-Jun transactivating activity
Ban et al., Mol Cell Biochem 2012
:
Furthermore, downregulation of
PPAR? by arginine
involved phosphorylation of
c-Jun that occurred before to changes in PPAR? transcriptional activity ... Silencing of
c-Jun increased
PPAR? beyond that of nonsilenced cells and was not mitigated by arginine
Ungaro et al., J Biol Chem 2012
:
These results indicate that
PPAR? regulates ped/pea-15 transcription by inhibiting
c-JUN binding at the ped/pea-15 promoter
Hou et al., Eur J Pharmacol 2013
:
To investigate the mechanisms involved, we found that
PPAR-? activation by rosiglitazone
inhibited the formation of c-fos/c-jun heterodimers and expression of
activator protein 1 induced by ANG II and thus inhibited transcription of the downstream genes involved in CFs proliferation and differentiation