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CIITA — IFNG

Text-mined interactions from Literome

Gourley et al., Immunity 1999 (Granuloma, Respiratory Tract) : This transcriptional control is observed in T cells differentiating to the Th1 but not Th2 lineage, consistent with induction of expression of the CIITA gene in T cells by IFNgamma
O'Keefe et al., Eur J Immunol 1999 : In this study, we investigated the effects of various immunomodulatory cytokines on IFN-gamma induction of class II MHC and CIITA gene expression in microglia, both primary microglia and a murine microglial cell line, EOC 20 ... TGF-beta1, IL-4, and IL-10 inhibition of IFN-gamma induced CIITA mRNA accumulation was not due to destabilization of CIITA mRNA, suggesting an effect at the level of transcription ... In primary murine microglia, IL-10 and TGF-beta1 inhibited IFN-gamma induced CIITA and class II MHC expression ... However, a discordant effect of IL-4 was noted in that IL-4 enhanced IFN-gamma induced CIITA and class II MHC expression in primary microglia
Itoh-Lindstrom et al., J Immunol 1999 (IgG Deficiency) : These findings demonstrate a requirement for CIITA in IFN-gamma- , IL-4-, and endotoxin induced MHC class II expression as well as the possibility of rare CIITA independent MHC class II expression
Nikcevich et al., J Neuroimmunol 1999 (Encephalomyelitis, Autoimmune, Experimental) : Here we demonstrate that IFN-gamma treatment of rat astrocytes induces only CIITA promoter IV activity in contrast to the murine macrophage cell line RAW 264.7 that uses both IFN-gamma-inducible promoters
Xi et al., Oncogene 1999 (Pancreatic Neoplasms) : IFN-gamma induced CIITA transcription in many cell types is directed by the CIITA Type IV promoter ... Finally, CIITA induction by IFN-gamma does not occur in a pancreatic tumor cell line that expresses a mutated IRF-2, representing the first IRF-2 mutation identified in a human tumor cell line
Lidington et al., Transpl Immunol 1999 : MHC class II antigens were not induced on ECV304 in response to IFN-gamma and nor was the class II transactivator (CIITA)
Kadota et al., Clin Exp Immunol 2000 (Thymoma...) : Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma)
Spilianakis et al., Mol Cell Biol 2000 : The class II transactivator (CIITA) , the master regulator of the tissue-specific and interferon gamma-inducible expression of major histocompatibility complex class II genes, synergizes with the histone acetylase coactivator CBP to activate gene transcription
van den Elsen et al., Hum Immunol 2000 (Choriocarcinoma) : Noteworthy, this lack of IFN-gamma mediated induction of CIITA was also found to exist in normal trophoblast cells expanded from chorionic villus biopsies
Eason et al., J Immunol 2001 (Cell Transformation, Neoplastic) : The induction of a high level of CIITA is dependent on sustained IFN-gamma signaling
O'Keefe et al., J Immunol 2001 : Here, we investigated the molecular regulation of IFN-gamma induced murine CIITA promoter IV activity in microglia/macrophages ... In the macrophage cell line RAW264.7, IFN-gamma inducibility of CIITA promoter IV is dependent on an IFN-gamma activation sequence ( GAS ) element and adjacent E-Box, and an IFN response factor ( IRF ) element, all within 196 bp of the transcription start site ... Functionally, the GAS, E-Box, and IRF elements are each essential for IFN-gamma induced CIITA promoter IV activity ... The effects of the suppressors of cytokine signaling-1 ( SOCS-1 ) protein on IFN-gamma induced CIITA and class II MHC expression were examined ... Ectopic expression of SOCS-1 inhibits IFN-gamma induced activation of CIITA promoter IV and subsequent class II MHC protein expression ... These results indicate that SOCS-1 may be responsible for attenuating IFN-gamma induced CIITA and class II MHC expression in macrophages
Dong et al., J Immunol 2001 : Previous studies have shown that the class II MHC transactivator (CIITA) , a master regulator that controls class II MHC expression, is targeted by TGF-beta for repression of IFN-gamma induced class II MHC expression in astrocytes ... In this study, we demonstrate that TGF-beta inhibition of CIITA expression occurs at the transcriptional level, and that both constitutive and IFN-gamma induced human CIITA type IV promoter activity is inhibited by TGF-beta
Goodwin et al., Cell Growth Differ 2001 (Melanoma) : In addition, we determined that constitutive CIITA expression is the result of the activation of both the B cell-specific CIITA promoter III and the IFN-gamma-inducible CIITA promoter IV, the latter of which previously has never been known to function as a constitutive promoter in any cell type
Xi et al., Oncogene 2001 : Both basal and IFN-gamma induced CIITA expression were reduced in IRF-2 knock-out mice ... The reduction of IFN-gamma induced CIITA mRNA in IRF-2 knock-out mice was due to the reduction of the type IV CIITA mRNA induction
van den Elsen et al., J Reprod Immunol 2001 : Furthermore, it was found that trophoblast cells lacked IFN-gamma mediated induction of the class II transactivator (CIITA)
Rahat et al., Int Immunol 2001 : Increased binding of IFN regulating factor 1 mediates the synergistic induction of CIITA by IFN-gamma and tumor necrosis factor-alpha in human thyroid carcinoma cells ... The aim of this study was to find whether CIITA is synergistically induced by IFN-gamma and TNF-alpha in the human thyroid MRO-87-1 cell line, and to investigate the molecular mechanisms responsible for this synergism ... We have demonstrated that IFN-gamma and TNF-alpha synergistically induce HLA-DRalpha and CIITA mRNAs, but prolonged incubation resulted in the inhibition of CIITA mRNA accumulation
van der Stoep et al., Int J Cancer 2002 (Burkitt Lymphoma...) : Lack of IFN-gamma mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines ... Considering the central role of the class II transactivator (CIITA) in MHC class II- and class I-mediated antigen presentation, we compared the induction of CIITA by interferon-gamma (IFN-gamma) in a diverse panel of developmental and more differentiated tumor cell lines
Sarol et al., Biochem Biophys Res Commun 2002 : We found that IFN-gamma induces CIITA through the JAK-STAT pathway and inhibits HIV-1 replication in latently infected cells
Kim et al., Diabetologia 2002 (Insulinoma...) : IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA ; nicotinamide reduced the expression of cytokine induced MHC class II expression on insulinoma cells through its effect on CIITA expression ; and the preventive effect of nicotimamide on Type I ( insulin dependent ) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis
Pattenden et al., EMBO J 2002 : We report that SWI/SNF is required for interferon (IFN)-gamma induction of CIITA , the master regulator of major histocompatibility complex class II expression ... Despite the presence of functional STAT1, IRF-1 and USF-1, activators implicated in CIITA expression, IFN-gamma did not induce CIITA in cells lacking BRG1 and hBRM, the ATPase subunits of SWI/SNF
Morris et al., Mol Cell Biol 2002 : In contrast to these events, fetal trophoblast-like cell lines, which are refractory to CIITA induction by IFN-gamma , failed to assemble the above factors or modify their chromatin, suggesting that accessibility to the promoter is blocked ... Together, this analysis provides a kinetic view of the activation of the CIITA gene in response to IFN-gamma and shows that regulatory factor assembly, chromatin modification, and gene expression proceed in discrete steps
Delvig et al., J Leukoc Biol 2002 : Consistent with the functional data, TGF-beta1 reduced the constitutive expression of MHC class II transactivator ( CIITA ), MHC class II (MHC-II), invariant chain, and DO mRNA, whereas IFN-gamma up-regulated the expression of CIITA and MHC-II mRNA without affecting invariant chain or DO mRNA ... Treatment of macrophages with the two cytokines in combination showed that TGF-beta1 down-regulated IFN-gamma mediated enhancement of antigen presentation and inhibited IFN-gamma-inducible CIITA and MHC-II class II mRNA expression
Pai et al., J Immunol 2002 : mRNA half-life was shorter for type I than type IV CIITA, suggesting that sustained transcription contributed to stable expression of type I CIITA induced by IFN-gamma
Xi et al., Mol Immunol 2003 : IFN-gamma induced transcription of class II transactivator (CIITA) , a major regulator of MHC class II gene expression, is directed by the CIITA type IV promoter
Pai et al., J Immunol 2003 : MTB and MTB 19-kDa lipoprotein inhibit class II MHC ( MHC-II ) expression and Ag processing by a Toll-like receptor 2-dependent mechanism that is shown in this study to involve a defect in IFN-gamma induction of class II transactivator (CIITA) ... Inhibition of IFN-gamma induced CIITA by MTB 19-kDa lipoprotein may allow MTB to evade detection by CD4 ( + ) T cells
Kim et al., J Immunol 2003 : Thyrotropin ( TSH ) represses IFN-gamma induced CIITA expression by inhibiting type IV CIITA promoter activity through the suppression of STAT1 activation and IFN regulatory factor 1 induction ... The cell line stably expressing the wild-type STAT3 showed a higher CIITA induction in response to IFN-gamma and also exhibited TSH repression of the IFN-gamma mediated induction of CIITA ... However, TSH repression of the IFN-gamma induced CIITA expression was not observed in FRTL-5 thyroid cells, which stably expresses the dominant negative forms of STAT3, STAT3-Y705F, and STAT3-S727A
Geirsson et al., Transplantation 2003 : TncRNA suppressed interferon-gamma induced human leukocyte antigen-DR and CIITA expression in HeLa cells
Giroux et al., J Immunol 2003 : Further analysis showed that IFN-gamma induced expression of the MHC class II transactivator ( CIITA ), a transcriptional coactivator essential for MHC-II expression, was inhibited in DN PKC-alpha overexpressing cells
Takeuchi et al., J Am Soc Nephrol 2003 (Disease Models, Animal...) : Expression of class II transactivator (CIITA) , the transcriptional regulator that controls all class II expression, is controlled in cell lines in vitro by three promoters : the dendritic cell promoter PI, the B cell promoter PIII, and the interferon-gamma (IFN-gamma)-inducible promoter, PIV
Croce et al., Oncogene 2003 (Neuroblastoma) : Interestingly, the use of DNA demethylating agents restored CIITA gene transcriptional activation by IFN-gamma , but not HLA class II expression
Doan et al., Oncogene 2004 : Lack of INI1 also did not prevent interferon gamma (IFNgamma) mediated induction of CIITA , which is BRG1 dependent, and GBP-1, which is BRG1 enhanced, and reintroduction of INI1 had minimal effects
You et al., Zhonghua Nei Ke Za Zhi 2004 (Hematologic Neoplasms) : It was found that the MHCII positive tumor cells expressed the CIITA quite well, and IFN-gamma could induce the expression of MHCI + II only if the tumor cells were able to express CIITA in an IFN-gamma induced manner ( 20 %, 42 % for Jurkat cells respectively ), while T cell expressed more IL-2 mRNA ( 51 times ) in the case of Jurkat after induction with IFN-gamma
Xu et al., J Biol Chem 2004 : Activation of MHC-II by IFN-gamma requires regulatory factor for X-box 5 (RFX5) complex as well as class II transactivator (CIITA) ... In addition, we are able to specifically knockdown the IFN-gamma stimulated expression of CIITA utilizing short hairpin interference RNA ( shRNA ) against CIITA
Piskurich et al., Mol Immunol 2006 : Expression of the MHC class II transactivator ( CIITA ) type IV promoter in B lymphocytes and regulation by IFN-gamma ... Although increases in MHC II expression in B cells in response to cytokines have been observed and induction of MHC II and CIITA by IFN-gamma has been studied in a number of different cell types, the specific effects of IFN-gamma on CIITA expression in B cells have not been studied ... To investigate the regulation of CIITA expression by IFN-gamma in B cells, RT-PCR, in vivo and in vitro protein/DNA binding studies, and functional promoter analyses were performed
Chou et al., Int Immunol 2005 : In the Colon 26 tumor IFN-gamma induced endogenous PIV-CIITA but not PIII-CIITA while TSA activated class II in the apparent absence of CIITA ... TSA treatment can also activate class II expression in mutant cell lines with deficiencies in signaling molecules, transcription factors and the BRG-1 cofactor that are required for IFN-gamma induced CIITA expression
Shi et al., Int J Biochem Cell Biol 2006 (Breast Neoplasms...) : The MHC class II and CIITA expression was restored in these cells upon stimulation with IFNgamma or by the treatment with a hypomethylating agent
Pazmany et al., J Neuroimmunol 2006 : Transforming growth factor-beta1 ( TGF-beta1 ) inhibits both type III- and IV-CIITA expression in EOC20 cells while, in EOC2 cells TGF-beta1 enhances IFN-gamma induced pIV-CIITA expression
Butticè et al., Circ Res 2006 (Atherosclerosis) : Interferon-gamma induces major histocompatibility class II transactivator (CIITA) , which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells ... However, simvastatin does not block the IFN-gamma induced expression of CIITA III and IV, suggesting a CIITA independent mechanism
Chen et al., Mol Immunol 2007 : In addition, IFN-gamma induces expression of CIITA in these cells through the type IV promoter ( pIV )
Yao et al., J Immunol 2006 (MAP Kinase Signaling System) : In macrophages, LPS inhibited IFN-gamma-inducible CIITA and MHC class II expression without affecting expression of IFN regulatory factor-1 and MHC class I. Blocking ERK and p38 by MAPK inhibitors not only rescued LPS mediated inhibition, but also augmented IFN-gamma induction of CIITA ... Moreover, the induction of CIITA by IFN-gamma was enhanced by overexpressing MAPK phosphatase-1 that inactivates MAPK
van der Stoep et al., Mol Immunol 2007 (Melanoma) : However, these components are readily recruited to the PURR and CIITA-PIV after exposure of cells to IFNgamma and account for the IFNgamma induced expression of CIITA
Kohoutek et al., Proc Natl Acad Sci U S A 2006 : Not only the exogenously expressed but also IFN-gamma induced CIITA was inhibited by Hexim1
Zhao et al., Mol Immunol 2007 (Multiple Myeloma) : Regulation of CIITA by IFN-gamma in B lymphocytes occurs through the CIITA type IV promoter ( pIV ), one of the four potential promoters ( pI-pIV ) of this gene ... To investigate regulation of CIITA by IFN-gamma in multiple myeloma cells, first the ability of these cells to respond to IFN-gamma was examined
Kwon et al., Mol Immunol 2007 : Therefore, we report, for the first time, that PKCdelta is an essential signaling molecule to achieve the maximal expression of CIITA in response to IFN-gamma in macrophages
Nikodemova et al., J Biol Chem 2007 (Demyelinating Autoimmune Diseases, CNS...) : Here we show that minocycline inhibited interferongamma (IFNgamma) induced CIITA and MHC II mRNA
He et al., Transpl Immunol 2007 : This is the first description that anti-CII TA M1-RNA could prevent IFN-gamma induced CII TA transcription and results in a decreased MHC-II expression in chondrocytes
Holling et al., J Immunol 2007 (Melanoma...) : A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma
Pennini et al., J Immunol 2007 : TLR2 signaling by Mycobacterium tuberculosis 19-kDa lipoprotein ( LpqH ) inhibits IFN-gamma induced expression of CIITA by macrophages ... Constitutive expression of C/EBPbeta LIP inhibited IFN-gamma induced CIITA expression in transfected cells ... In summary, LpqH induced expression of C/EBPbeta and C/EBPdelta, and their binding to CIITA pI and pIV, in correlation with inhibition of IFN-gamma induced expression of CIITA in macrophages, suggesting a role for C/EBP as a novel regulator of CIITA expression
Xu et al., J Biol Chem 2008 : CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation dependent interactions with co-repressor molecules
Meissner et al., Br J Dermatol 2008 (Carcinoma, Squamous Cell...) : One cell line displayed a loss of IFN-gamma induced CIITA-expression that corresponded to impaired MHC class II surface expression, which could be linked to hypermethylation of the IFN-gamma-responsive CIITA-promoter IV
Xu et al., J Biol Chem 2008 : We further identify that increased cellular cAMP levels are responsible for the down-regulation of CIITA expression and, hence, reduced IFN-gamma response as evidenced by the following data : 1 ) direct activation of adenylyl cyclase activity is both necessary and sufficient to suppress the IFN-gamma response ; 2 ) inhibition of phosphodiesterase activity attenuates IFN-gamma induced transcription events ; and 3 ) direct treatment with cAMP analog abrogates CIITA activation and IFN-gamma response
Uetani et al., Eur J Immunol 2008 : Influenza A virus infection inhibited IFN-gamma induced up-regulation of HLA-DRalpha mRNA and the IFN-gamma induction of class II transactivator (CIITA) , an obligate mediator of MHC class II expression
Itoh et al., J Neuroimmunol 2009 : Interferon-gamma mediated transcriptional induction of CIITA , a critical regulator of MHC-II induction, was 6-fold lower in mature oligodendrocytes than in OPC, and entirely dependent on promoter IV, suggesting that the transcriptional activity of promoter IV is down-regulated after differentiation
Benson et al., PloS one 2009 : Using chromatin immunoprecipitation, we found that TLR2 stimulation inhibited IFN-gamma induced RNA polymerase II binding to the CIITA and CXCL11 promoters
Hardy et al., Immunology 2009 : In addition, inhibition of PI3K, but not of p38 MAPK, strongly impaired IFN-gamma induced CIITA and MHC II gene expression ... Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Mahmoud et al., Int Immunopharmacol 2010 : In agreement with this, treatment of the cells with capsaicin also inhibited MHC class II transactivator ( CIITA ) mRNA expression induced by IFN-gamma in a dose dependent manner
Fang et al., Eur J Immunol 2013 : MRS-1754 blocked the antagonism of transforming growth factor beta ( TGF-ß ) in CIITA induction by interferon gamma ( IFN-? ) , alluding to a potential dialogue between TGF-ß and adenosine signaling pathways
Lu et al., J Exp Med 1995 (Fibrosarcoma) : We studied the status of IFN-gamma induced CIITA messenger RNA ( mRNA ) accumulation and CIITA-driven transactivation in IFN-beta treated cells and used cell lines that had defined defects in the type I IFN response pathway to address the roles of IFN signaling components in the inhibition of MHC class II induction
Tschickardt et al., Int J Cancer 1995 : We also examined the IFN-gamma induction of CIITA in RB-defective lines
Lee et al., J Immunol 1996 (Astrocytoma...) : These findings demonstrate that Stat1 alpha is involved in IFN-gamma induction of CIITA expression, resulting in class II MHC expression
Lu et al., J Immunol 1996 (Carcinoma, Non-Small-Cell Lung...) : IFN-gamma induction of CIITA , a major regulator of class II transcription, suggested that H2009 retained at least part of the IFN-gamma signaling pathway leading to class II expression
Ramassar et al., Transplantation 1996 : CIITA induction by IFN-gamma was partially sensitive to cycloheximide, suggesting that another protein is required for CIITA induction
Nandan et al., J Immunol 1997 : This conclusion is based on the finding that induction of CIITA gene expression in response to IFN-gamma is completely abrogated in TGF-beta treated cells
Lee et al., J Immunol 1997 (Astrocytoma...) : In this study, we provide evidence that TGF-beta blocks IFN-gamma induced CIITA mRNA accumulation ... Cell lines that possessed defects in TGF-beta signaling also became refractory to inhibition of IFN-gamma induced CIITA and class II MHC expression
Vedrenne et al., Oncogene 1997 : The class II transactivator (CIITA) is necessary for both constitutive and IFN-gamma induced MHC class II expressions
Lu et al., Immunol Cell Biol 1997 : Examination of additional cell lines for GBP and CIITA induction revealed that a specific lack of the CIITA IFN-gamma response is common in human tumour lines
Muhlethaler-Mottet et al., Immunity 1998 : Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1 ... We show here that three cis acting elements, the GAS, the E box, and the IRF-1 binding site, as well as the transacting factors Stat1 and IRF-1, are essential for activation of CIITA promoter IV by IFNgamma ... The specificity for CIITA activation by IFNgamma is thus dictated by the GAS/E box motif and by the selective interaction of IFNgamma activated Stat1 and USF-1
Piskurich et al., J Immunol 1998 : Although the role of CIITA is greatly appreciated, the mechanisms underlying constitutive and IFN-gamma induced expression of CIITA are not understood ... In contrast, inducible activation of CIITA by IFN-gamma requires sequences contained in an additional 4 kb of upstream DNA ... TGF-beta significantly inhibits IFN-gamma mediated induction of the CIITA promoter in 2fTGH fibroblasts, which indicates that the promoter is a target for TGF-beta
Van Wagoner et al., J Neuroimmunol 1998 (Astrocytoma...) : In this study, we examined the necessity of ser/thr and tyr kinase activity for IFN-gamma induced stimulation of class II MHC gene expression in the human astroglioma cell lines CRT and CH235, as well as the involvement of these kinases in IFN-gamma induced expression of the class II transactivator (CIITA) , a protein critical for IFN-gamma induced transcription of class II MHC genes ... As well, these inhibitors abrogate IFN-gamma induced CIITA mRNA expression in the astroglioma cell lines
Navarrete Santos et al., Int Immunol 1998 (Arthritis, Rheumatoid) : TGF-beta1, additionally, down-regulated IFN-gamma stimulated class II transactivator (CIITA) and DRB mRNA expression
Sartoris et al., J Immunol 1998 (Adenocarcinoma...) : Transfection of an expressible CIITA cDNA in Alexander cells resulted in a very high cell surface expression of all three human class II subsets, HLA-DR, -DP and -DQ, indicating that normally observed induction of CIITA expression by IFN-gamma is probably blocked, in the hepatocarcinoma cell lines, at the level of CIITA transcription and not at the level of IFN-gamma receptor binding and signal transduction mechanisms
Murphy et al., Mol Reprod Dev 1998 : The absence of CIITA gene expression in trophoblasts treated with IFN-gamma does not result from a defect in the IFN-gamma receptor or the JAK/STAT pathway, because the classical IFN-gamma inducible gene encoding the guanylate binding protein is expressed
Morris et al., Am J Reprod Immunol 1998 : However, CIITA expression was absent in trophoblasts and could not be induced by IFN-gamma
Rohn et al., J Immunol 1999 (Astrocytoma) : Furthermore, we demonstrate that IFN-gamma induction of CIITA mRNA expression is inhibited by treatment of cells with IL-1beta