Houten et al., Cell Mol Life Sci 2009
:
We show that AMP activated protein kinase (AMPK) activation by hypoxia and AICAR treatment combined with fatty acid administration synergistically induce PDK4 expression
Wu et al., Biochim Biophys Acta 2013
(Neoplasms) :
Taken together, we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS/AMPK dependent activation of PDK