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SPARC — VEGFA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kato et al., Biochem Biophys Res Commun 2001
:
Induction of
SPARC by
VEGF in human vascular endothelial cells ... Although SPARC derived peptide showed an angiogenic effect, intact
SPARC itself
inhibited the mitogenic activity of
vascular endothelial growth factor ( VEGF ) for ECs by the inhibiting phosphorylation of flt-1 ( VEGF receptor 1 ) and subsequent ERK activation ... To clarify the role of SPARC in tumor growth and progression, we determined the
effect of
VEGF on the expression of
SPARC in human microvascular EC line, HMEC-1, and human umbilical vein ECs ...
VEGF increased the levels of
SPARC protein and steady-state levels of SPARC mRNA in serum starved HMEC-1 cells ... Inhibitors ( SB202190 and SB203580 ) of p38, a mitogen activated protein ( MAP ) kinase, attenuated
VEGF stimulated
SPARC production in ECs
Bradshaw et al., Wound Repair Regen 2001
:
In addition,
SPARC binds to and
diminishes the mitotic activity of
vascular endothelial growth factor
De et al., J Biol Chem 2003
(Bone Neoplasms...) :
Within the bone environment,
SPARC engagement of these integrins will
stimulate growth of the tumor and further production of
VEGF to support neoangiogenesis, thereby favoring the development of the metastatic tumor
Said et al., Mol Cancer Res 2007
(Carcinoma...) :
SPARC inhibited the
VEGF- and integrin mediated ID8 proliferation in vitro and significantly suppressed their tumorigenicity in vivo
Zhang et al., PloS one 2012
(Neovascularization, Pathologic...) :
Endogenous
SPARC overexpression
inhibited the expression of
VEGF and MMP-7, as well as the angiogenesis induced by BGC-SP cells
Kupprion et al., J Biol Chem 1998
:
SPARC thus modulates the mitogenic activity of VEGF through a direct binding interaction and
reduces the association of
VEGF with its cell-surface receptors