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MSX2 — TNF

Text-mined interactions from Literome

Lee et al., Exp Mol Med 2010 : Furthermore, TNF-alpha induced Msx2 expression, and the knockdown of Msx2 by small interfering RNAs rescued ALP expression, which was inhibited by TNF-alpha ... Inhibition of NF-kappaB or JNK activation reduced the inhibitory effect of TNF-alpha on ALP expression, whereas TNF-alpha induced Msx2 expression was only suppressed by the inhibition of the NF-kappaB pathway
Lai et al., Endocrinology 2012 : To better understand this biology, we studied TNF actions on Msx2 in aortic myofibroblasts ... Consistent with this, rotenone, an antagonist of mitochondrial complex I, inhibited TNF induction of Msx2 and Nox2, whereas pyruvate, an anapleurotic mitochondrial metabolic substrate, enhanced induction ... Thus, ROS metabolism contributes to TNF induction of Msx2 and procalcific responses in myofibroblasts via TNFR1