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GRPR — PTGS2

Text-mined interactions from Literome

Guo et al., J Biol Chem 2001 (Cell Transformation, Neoplastic...) : Overexpression of these proteins is associated with altered epithelial cell growth, adhesion, and tumor cell invasiveness, both in vitro and in vivo ; however, a mechanistic link between GRP-R mediated signaling pathways and increased COX-2 overexpression has not been established
Wen et al., BMC molecular biology 2011 (Prostatic Neoplasms) : Although BBS stimulates nuclear factor-kappaB ( NF-?B ) in PC-3, NF-?B does not regulate GRPR mediated COX-2 expression ... Expression of recombinant GRPR in the androgen-sensitive cell line LNCaP is sufficient to confer BBS stimulated COX-2 expression via the p38MAPK and PI3K/Akt pathways