Gene interactions and pathways from curated databases and text-mining

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CFTR — VIP

Text-mined interactions from Literome

Robert et al., J Physiol 2005 : Using an iodide efflux assay we demonstrated stimulation of CFTR by VIP , isoproterenol, cAMP agonists and other pharmacological activators in cultured VSMC from Cftr ( +/+ )
Chappe et al., J Pharmacol Exp Ther 2008 : VIP induced accumulation of apical CFTR was mimicked by phorbol ester but not by forskolin, and it was blocked by the protein kinase ( PK ) C inhibitors bisindolylmaleimide X ( BisX ) or chelerythrine chloride but not by the PKA inhibitor N- [ 2- ( p-bromocinnamylamino ) ethyl ] -5-isoquinolinesulfonamide dihydrochloride ( H89 )
Rafferty et al., J Pharmacol Exp Ther 2009 (Cystic Fibrosis) : In the present study, we investigated the effect of VIP on F508del-CFTR activity and membrane insertion in the human nasal epithelial cell line JME/CF15, which also expresses the VPAC(1) receptor