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PGP — RHOA

Text-mined interactions from Literome

Kobori et al., Eur J Pharm Sci 2012 (Pain) : Recent studies have revealed that RhoA , a small G-protein, is involved in the regulation of P-gp expression and activity ... Here, we examined the involvement of RhoA in the changes in ileal P-gp protein expression and activity induced by repeated orally administered ETP ... RhoA activation induced by repeated oral ETP administration may be involved in the up-regulation of ileal P-gp protein expression and activity, leading to a decrease in the analgesic effect of oral morphine
Kobori et al., J Pharm Sci 2013 : Repeated oral treatment with ETP significantly increased the ileal membrane localization of ERM and phosphorylated ERM ( p-ERM ) in association with upregulation of P-gp and activation of RhoA and ROCK