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GRB2 — SPN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: GRB2/SHC1/VAV Family complex (GRB2-SHC1) → SPN (increases, GRB2/SHC1 Activity) Pedraza-Alva et al., J Biol Chem 1998*
  Evidence: Here we show that CD43-specific activation of human T lymphocytes induced tyrosine phosphorylation of the adaptor protein Shc and of the guanine exchange factor Vav, as well as the formation of a macromolecular complex that comprises Shc, GRB2, and Vav. CD43 ligation resulted in enhanced formation of Vav.SLP-76 complexes and in the activation and nuclear translocation of ERK2.