Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
JAK2
→
Complex of IGF1-IGF1R
(increases)
Zong et al., J Biol Chem 2000* Evidence: We found that STAT3, but not STAT5, was activated in response to IGF-I in 293T cells cotransfected with IGF-IR and STAT expression vectors. Moreover, tyrosine phosphorylation of STAT3, JAK1, and JAK2 was increased upon IGF-I stimulation of endogenous IGF-IR in 293T cells transfected with the respective STAT or JAK expression vector.
OpenBEL Selventa BEL large corpus:
JAK2
→
IGF1R
(increases, IGF1R Activity, JAK2 Activity)
Zong et al., J Biol Chem 2000* Evidence: tyrosine phosphorylation of STAT3, JAK1, and JAK2 was increased upon IGF-I stimulation of endogenous IGF-IR in 293T cells transfected with the respective STAT or JAK expression vector.
OpenBEL Selventa BEL large corpus:
JAK2
→
IGF1R
(increases, JAK2 Activity)
Gual et al., Endocrinology 1998* Evidence: Insulin and insulin-like growth factor-1 (IGF-1) treatment of cells overexpressing the insulin receptor or the IGF-1 receptor promotes phosphorylation and activation of Janus kinases JAK-1 and JAK-2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *