Gene interactions and pathways from curated databases and text-mining

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EIF3A — EIF3M

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pilipenko et al., Genes Dev 2000 : Reconstitution of initiation using fully fractionated translation components indicated that 48S complex formation on both IRESs requires eIF2, eIF3 , eIF4A, eIF4B, eIF4F, and the pyrimidine tract binding protein (PTB) but that the FMDV IRES additionally requires ITAF ( 45 ), also known as murine proliferation associated protein ( Mpp1 ), a proliferation dependent protein that is not expressed in murine brain cells
Korneeva et al., J Biol Chem 2000 : Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ; eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of eIF4G increased 2.4-fold in the presence of eIF3 ... Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ; eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of eIF4G increased 2.4-fold in the presence of eIF3
Ling et al., Mol Cell Biol 2002 : The translational function of SLBP genetically required eukaryotic initiation factor 4E (eIF4E), eIF4G, and eIF3 , and expressed SLBP coisolated with S. cerevisiae initiation factor complexes that bound the 5 ' cap in a manner dependent on eIF4G and eIF3
Li et al., Shi Yan Sheng Wu Xue Bao 2003 : As the largest subunit, eIF3a mediates most functions of eIF3
Hui et al., J Biol Chem 2003 : These assays examined the effect of p56 on ribosome dissociation, the eIF3.eIF4F interaction, and enhancement of the ternary complex eIF2.GTP.Met-tRNAi formation
Singh et al., J Biol Chem 2004 : Physical association of eukaryotic initiation factor (eIF) 5 carboxyl-terminal domain with the lysine-rich eIF2beta segment strongly enhances its binding to eIF3
Harris et al., EMBO J 2006 : mTOR dependent stimulation of the association of eIF4G and eIF3 by insulin
Nielsen et al., Mol Cell Biol 2006 : Several findings indicate that the rnp1 lesion decreases recruitment of eIF3 to the 40S subunit by HCR1 : ( i ) rnp1 strongly impairs the association of HCR1 with PRT1 without substantially disrupting the eIF3 complex ; ( ii ) rnp1 impairs the 40S binding of eIF3 more so than the 40S binding of HCR1 ; ( iii ) overexpressing HCR1-R215I decreases the Ts ( - ) phenotype and increases 40S bound eIF3 in rnp1 cells ; ( iv ) the rnp1 Ts ( - ) phenotype is exacerbated by tif32-Delta6, which eliminates a binding determinant for HCR1 in TIF32 ; and ( v ) hcr1Delta impairs 40S binding of eIF3 in otherwise wild-type cells
Damoc et al., Mol Cell Proteomics 2007 : The eIF3 complex also prevents premature association of the 40 and 60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection
Morris et al., EMBO Rep 2007 : From these observations, we propose that INT6 , in association with eIF3 , is involved in routing specific mRNAs for degradation
Pestova et al., EMBO J 2008 : Although 48S complexes assembled both by eIF2/eIF3- and eIF5B/eIF3 mediated Met-tRNA ( iMet ) recruitment were destabilized by eIF1, dissociation of 48S complexes formed with eIF2 could be out competed by efficient subunit joining
Lane et al., PloS one 2013 : Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27 ( kip1 ) expression during iron depletion ... Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27 ( kip1 ) expression during iron depletion