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EIF3A — EIF3M
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EIF3A
—
EIF3M
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
EIF3A
—
EIF3M
(physical association, affinity chromatography technology)
Ewing et al., Molecular systems biology 2007
-
MIPS CORUM eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1):
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) complex (EIF3A-EIF3B-EIF3C-EIF3D-EIF3E-EIF3L-EIF3F-EIF3G-EIF3H-EIF3I-EIF3J-EIF3K-EIF3M)
Damoc et al., Mol Cell Proteomics 2007
-
IRef Dip Interaction:
EIF3A
—
EIF3M
(physical association, pull down)
Querol-Audi et al., Structure 2013
-
IRef Dip Interaction:
Complex of 27 proteins
(physical association, mass spectrometry studies of complexes)
Zhou et al., Proc Natl Acad Sci U S A 2008
-
IRef Dip Interaction:
Complex of 89 proteins
(physical association, molecular sieving)
Querol-Audi et al., Structure 2013
-
IRef Dip Interaction:
Complex of 37 proteins
(physical association, transmission electron microscopy)
Querol-Audi et al., Structure 2013
-
IRef Dip Interaction:
Complex of 37 proteins
(physical association, molecular sieving)
Querol-Audi et al., Structure 2013
-
Gene Ontology Complexes eukaryotic translation initiation factor 3 complex, eIF3m:
eukaryotic translation initiation factor 3 complex, eIF3m complex (EIF3H-EIF3I-EIF3D-EIF3M-EIF3A)
-
IRef Intact Interaction:
EIF3A
—
EIF3M
(physical association, anti bait coimmunoprecipitation)
Ewing et al., Molecular systems biology 2007
-
IRef Intact Interaction:
Complex of 39 proteins
(association, pull down)
Jäger et al., Nature 2012
-
IRef Intact Interaction:
Complex of 185 proteins
(association, tandem affinity purification)
Zhang et al., EMBO J 2013
-
IRef Intact Interaction:
Complex of 18 proteins
(physical association, tandem affinity purification)
Hutchins et al., Science 2010
-
STRING interaction:
EIF3M
—
EIF3A
(interaction, mapped from grid)
-
STRING interaction:
EIF3A
—
EIF3M
(interaction, mapped from grid)
Text-mined interactions from Literome
Pilipenko et al., Genes Dev 2000
:
Reconstitution of initiation using fully fractionated translation components indicated that
48S complex formation on both IRESs
requires eIF2,
eIF3 , eIF4A, eIF4B, eIF4F, and the pyrimidine tract binding protein (PTB) but that the FMDV IRES additionally requires ITAF ( 45 ), also known as murine proliferation associated protein ( Mpp1 ), a proliferation dependent protein that is not expressed in murine brain cells
Korneeva et al., J Biol Chem 2000
:
Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ;
eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of eIF4G
increased 2.4-fold in the presence of
eIF3 ... Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ; eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of
eIF4G increased 2.4-fold in the presence of
eIF3
Ling et al., Mol Cell Biol 2002
:
The translational function of
SLBP genetically
required eukaryotic initiation factor 4E (eIF4E), eIF4G, and
eIF3 , and expressed SLBP coisolated with S. cerevisiae initiation factor complexes that bound the 5 ' cap in a manner dependent on eIF4G and eIF3
Li et al., Shi Yan Sheng Wu Xue Bao 2003
:
As the largest subunit,
eIF3a mediates most functions of
eIF3
Hui et al., J Biol Chem 2003
:
These assays examined the
effect of
p56 on ribosome dissociation, the
eIF3.eIF4F interaction, and enhancement of the ternary complex eIF2.GTP.Met-tRNAi formation
Singh et al., J Biol Chem 2004
:
Physical association of
eukaryotic initiation factor (eIF) 5 carboxyl-terminal domain with the lysine-rich eIF2beta segment strongly
enhances its binding to
eIF3
Harris et al., EMBO J 2006
:
mTOR dependent stimulation of the association of eIF4G and
eIF3 by insulin
Nielsen et al., Mol Cell Biol 2006
:
Several findings indicate that the rnp1 lesion decreases recruitment of eIF3 to the 40S subunit by HCR1 : ( i ) rnp1 strongly impairs the association of HCR1 with PRT1 without substantially disrupting the eIF3 complex ; ( ii ) rnp1 impairs the 40S binding of eIF3 more so than the 40S binding of HCR1 ; ( iii ) overexpressing
HCR1-R215I decreases the Ts ( - ) phenotype and
increases 40S bound
eIF3 in rnp1 cells ; ( iv ) the rnp1 Ts ( - ) phenotype is exacerbated by tif32-Delta6, which eliminates a binding determinant for HCR1 in TIF32 ; and ( v ) hcr1Delta impairs 40S binding of eIF3 in otherwise wild-type cells
Damoc et al., Mol Cell Proteomics 2007
:
The
eIF3 complex also
prevents premature association of the 40 and
60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection
Morris et al., EMBO Rep 2007
:
From these observations, we propose that
INT6 , in association with
eIF3 , is
involved in routing specific mRNAs for degradation
Pestova et al., EMBO J 2008
:
Although 48S complexes assembled both by
eIF2/eIF3- and
eIF5B/eIF3 mediated Met-tRNA ( iMet ) recruitment were destabilized by eIF1, dissociation of 48S complexes formed with eIF2 could be out competed by efficient subunit joining
Lane et al., PloS one 2013
:
Importantly,
eIF3a positively regulated NDRG1 expression and negatively
regulated p27 ( kip1 ) expression during iron depletion ... Importantly,
eIF3a positively
regulated NDRG1 expression and negatively regulated p27 ( kip1 ) expression during iron depletion