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CREB3 — CYP19A1
Text-mined interactions from Literome
Sofi et al., Breast Cancer Res Treat 2003
(Breast Neoplasms) :
Role of
CRE binding protein ( CREB ) in
aromatase expression in breast adipose
Sirianni et al., J Biol Chem 2009
:
Inhibitors for COX-2 ( NS398 ), EP4 ( AH23848 ), and PKA ( H89 ) decreased
aromatase expression and activity as a
consequence of a decreased phosphorylated
CREB recruitment to the PII promoter of the aromatase gene
Brown et al., Cancer Res 2010
(Breast Neoplasms...) :
In postmenopausal women, the
CREB dependent regulation of
aromatase is a crucial determinant of breast tumor formation through local production of estrogens
Carlone et al., Mol Endocrinol 1997
:
Taken together, the data indicate that expression of the
aromatase gene is dependent on the additive interactions of regions A and B of the aromatase promoter in granulosa cells and the synergistic interactions of these same regions in R2C cells and that these interactions are
dependent , in turn, on the phosphorylation of
CREB and SF-1 and the content of these factors, as well as the presence of putative coregulatory molecules