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ALS7 — SOD1
Text-mined interactions from Literome
Pasinelli et al., Proc Natl Acad Sci U S A 2000
(Amyotrophic Lateral Sclerosis) :
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn
superoxide dismutase mediated familial
amyotrophic lateral sclerosis
Shimizu et al., J Chromatogr B Analyt Technol Biomed Life Sci 2002
:
Variant
SOD-1 causes
amyotrophic lateral sclerosis
Parton et al., Hum Mutat 2002
(Amyotrophic Lateral Sclerosis) :
D90A-SOD1 mediated
amyotrophic lateral sclerosis : a single founder for all cases with evidence for a Cis acting disease modifier in the recessive haplotype
Potter et al., J Biol Inorg Chem 2003
(Amyotrophic Lateral Sclerosis) :
The perplexing
role of copper-zinc
superoxide dismutase in
amyotrophic lateral sclerosis ( Lou Gehrig 's disease )
Takeuchi et al., J Neurochem 2004
(Amyotrophic Lateral Sclerosis...) :
Mutant
SOD1s cause familial
amyotrophic lateral sclerosis ( FALS ) through the gain of unelucidated toxic properties
Ge et al., J Biol Chem 2005
:
The mechanism by which mutated copper-zinc
superoxide dismutase ( SOD1 )
causes familial
amyotrophic lateral sclerosis is believed to involve an adverse gain of function, independent of the physiological antioxidant enzymatic properties of SOD1
Lobsiger et al., Proc Natl Acad Sci U S A 2005
(Amyotrophic Lateral Sclerosis) :
Eliminating assembled neurofilaments ( NFs ) from axons or misaccumulating NFs in motor neuron cell bodies strongly slows disease in mouse models of mutant
superoxide dismutase 1 (SOD1) induced
amyotrophic lateral sclerosis
Garcia et al., Neurobiol Dis 2006
(Amyotrophic Lateral Sclerosis...) :
Mutations in neurofilament genes are not a significant primary cause of
non-SOD1 mediated
amyotrophic lateral sclerosis
Nawa et al., Cell Signal 2008
(Amyotrophic Lateral Sclerosis) :
A novel Akt/PKB interacting protein promotes cell adhesion and inhibits familial
amyotrophic lateral sclerosis linked mutant
SOD1 induced neuronal death via inhibition of PP2A mediated dephosphorylation of Akt/PKB
Jaarsma et al., J Neurosci 2008
(Amyotrophic Lateral Sclerosis...) :
Neuron-specific expression of mutant
superoxide dismutase is
sufficient to induce
amyotrophic lateral sclerosis in transgenic mice
Yang et al., J Neurosci 2009
(Amyotrophic Lateral Sclerosis) :
Reticulon-4A ( Nogo-A ) redistributes protein disulfide isomerase to protect mice from
SOD1 dependent
amyotrophic lateral sclerosis
Graffmo et al., Hum Mol Genet 2013
(Amyotrophic Lateral Sclerosis) :
Expression of wild-type human
superoxide dismutase-1 in mice
causes amyotrophic lateral sclerosis
Zetterström et al., Neuromolecular Med 2013
(Amyotrophic Lateral Sclerosis...) :
They may be the primary cause of toxicity in
superoxide dismutase-1 induced
amyotrophic lateral sclerosis
Saccon et al., Brain 2013
(Amyotrophic Lateral Sclerosis) :
Here, we bring together historical and recent experimental findings to conclude that there is a possibility that
SOD1 loss of function may
play a modifying role in
amyotrophic lateral sclerosis
Pickles et al., Hum Mol Genet 2013
(Amyotrophic Lateral Sclerosis...) :
Mutant superoxide dismutase 1 (SOD1) selectively associates with spinal cord mitochondria in rodent models of
SOD1 mediated
amyotrophic lateral sclerosis