Gene interactions and pathways from curated databases and text-mining

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BIRC3 — TNF

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., J Biol Chem 1999 (Neoplasms) : PG490 also blocked TNF-alpha mediated induction of c-IAP2 ( hiap-1 ) and c-IAP1 ( hiap-2 ), members of the inhibitor of apoptosis (IAP) family
Pryhuber et al., Am J Respir Cell Mol Biol 2000 (Pneumonia) : Tumor necrosis factor-alpha induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2
Varghese et al., J Immunol 2001 : TNF induced expression of the antiapoptotic protein c-IAP2 ( cytoplasmic inhibitor of apoptosis protein 2 ), and was blocked in the presence of a p38 MAPK inhibitor, which also induced caspase dependent, TNF mediated apoptosis in U937 cells
Niesler et al., Int J Obes Relat Metab Disord 2001 (Obesity) : These results demonstrate that cIAP2 is expressed in a depot-specific manner in human preadipocytes and that levels of expression are regulated by serum factors and TNFalpha
Furusu et al., Kidney Int 2001 : In response to TNF-alpha , expression of c-IAP1 and c-IAP2 was induced in HeLa cells and ECV304 endothelial cells, but not in mesangial cells
Ludeman et al., J Biol Chem 2005 : APC and thrombin both triggered PAR1 mediated responses in endothelial cells including expression of antiapoptotic ( tumor necrosis factor-alpha induced a20 and iap-1 ) and chemokine ( interleukin-8 (il-8) and cxcl3 ) genes, but again, APC was approximately 10 ( 4 ) -fold less potent than thrombin
Yang et al., Invest Ophthalmol Vis Sci 2005 : Overexpression of mutant IkappaB blocked TNF-alpha induced TRAF-1, TRAF-2, c-IAP1 , c-IAP2, c-FLIP, and A1 gene expression and downregulated TRAF-1 protein levels
Mishra et al., J Biol Chem 2005 (Calcium Signaling) : Our results suggest that LPS and TNF-alpha induced c-IAP2 expression was regulated by calmodulin (CaM) through the activation of calmodulin dependent protein kinase-II ( CaMKII ) ... Taken together, these results suggest that LPS- and TNF-alpha induced c-IAP2 expression and its associated antiapoptotic survival signals in THP-1 cells are regulated selectively by CaM/CaMKII through NF-kappaB activation
Furusu et al., J Cell Physiol 2007 : In human endothelial cells, TNF-alpha induced c-IAP1 and c-IAP2 , but not XIAP and TIAP/Survivin, at the transcriptional level ... In contrast, extracellular signal regulated kinase, p38 MAP kinase, and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha, and inhibition of each kinase by PD098059, SB203580, curcumin, or SP600125 substantially attenuated the TNF-alpha induced c-IAP1 and c-IAP2 expression ... These data indicated that TNF-alpha induced expression of c-IAP1 and c-IAP2 via MAP kinases, but not via NF-kappaB, and that MAP kinases participated in the inhibition of apoptosis by induction of c-IAPs in TNF-alpha stimulated endothelial cells
Karrasch et al., PloS one 2007 (Colitis) : In vitro, luteolin sensitized colonic epithelial HT29 cells to TNFalpha induced apoptosis, caspase 3 activation, DNA fragmentation and reduced TNFalpha induced C-IAP1 , C-IAP2 and COX-2 gene expression
Petersen et al., Proc Natl Acad Sci U S A 2010 (Carcinoma, Non-Small-Cell Lung...) : cIAP2 is induced by TNFalpha via NF-kappaB and modulation of the NF-kappaB signal renders otherwise resistant cells sensitive to Smac mimetics
Zhao et al., J Neurooncol 2011 (Brain Neoplasms...) : We demonstrate that in the absence of p65, TNF-a induced cIAP2 expression is significantly reduced while the levels of Bcl-2, Bcl-xL and Survivin are not affected
Park et al., Biochem Pharmacol 2011 (Inflammation...) : Triptolide also abrogated TNF induced expression of cell survival proteins ( XIAP, Bcl-x ( L ), Bcl-2, survivin, cIAP-1 and cIAP-2 ), cell proliferative proteins ( cyclin D1, c-myc and cyclooxygenase-2 ), and metastasis proteins ( ICAM-1 and MMP-9 )
Tan et al., Diabetologia 2013 : TNF-a selectively induced Birc3 in beta cells, which in turn was sufficient to drive and potentiate NF-?B reporter activity
Song et al., Int Immunopharmacol 2013 : Here, we show that pro-inflammatory cytokine TNF-a induced the up-regulation of c-IAP2 in the potential metastatic nasopharyngeal carcinoma (NPC) cells in a dose- and time dependent manner
Chu et al., Proc Natl Acad Sci U S A 1997 : These findings suggest that c-IAP2 is critically involved in TNF signaling and exerts positive feedback control on NF-kappaB via an IkappaB targeting mechanism
Montague et al., Diabetes 1998 : Because cIAP2 may be involved in the regulation of TNF-alpha signaling, this raises the possibility that depot-specific differences may exist in the regulation of adipocyte apoptosis