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CDH5 — TNF
Text-mined interactions from Literome
Hofmann et al., Eur J Med Res 2002
:
We investigated whether
TNF-alpha regulates the synthesis of
VE-cadherin on the transcriptional level ... Our results indicate that
TNF-alpha affects VE-cadherin gene expression on the transcriptional level,
inducing a downregulation of the
VE-cadherin expression
Nwariaku et al., Shock 2002
:
The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in
TNF induced changes in
cadherin expression ... The purpose of our study was to determine the
effect of
TNFalpha on
VE-cadherin cell-surface expression and to identify the signaling pathways involved in TNF induced changes in cadherin expression ... Inhibition of p38 but not ERK MAPK significantly reduced the
effect of
TNFalpha on endothelial permeability and cell-surface
VE cadherin expression
Ferrero et al., FASEB J 2004
(Capillary Leak Syndrome...) :
Studies of the mechanism of action showed that CgA inhibits
TNF induced
VE-cadherin down-regulation and barrier alteration of cultured endothelial cells, in an indirect manner
Nwariaku et al., Blood 2004
:
We found that
tumor necrosis factor (TNF) caused tyrosine phosphorylation of
VE-cadherin , separation of lateral cell-cell junctions, and intercellular gap formation in human umbilical vein endothelial cell ( HUVEC ) monolayers ... Finally, adenoviral delivery of the kinase dead PAK1 ( K298A ) decreased
TNF induced JNK activation,
VE-cadherin phosphorylation, and lateral junctional separation, consistent with the proposed involvement of PAK1 upstream of the NADPH oxidase
Ding et al., Int Immunopharmacol 2005
:
Furthermore, it was found that ESM attenuated the disorganization of
vascular endothelial (VE)-cadherin induced by
TNF-alpha
Angelini et al., Am J Physiol Lung Cell Mol Physiol 2006
:
TNF-alpha increases tyrosine phosphorylation of
vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia ... PP2 also blocked
TNF-alpha induced tyrosine phosphorylation of
VE-cadherin , gamma-catenin, and p120(ctn)
Böckeler et al., J Infect Dis 2007
(Marburg Virus Disease) :
We showed that mediators released from MARV infected monocytes/macrophages, as well as recombinant
tumor necrosis factor (TNF)- alpha /H2O2 and interferon (IFN)- gamma,
caused tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 ( PECAM-1 ) but not of the
vascular endothelial (VE) cadherin/catenin complex proteins
Vandooren et al., Arthritis Rheum 2008
(Rheumatic Diseases) :
In vitro,
cadherin 11 expression by FLS was consistently
up-regulated by
tumor necrosis factor alpha (TNFalpha) at the protein, but not the messenger RNA, level
Cain et al., J Cell Biol 2010
:
We find that depletion of p110alpha but not other p110 isoforms decreases
TNF induced endothelial permeability, Tyr phosphorylation of the adherens junction protein
vascular endothelial cadherin ( VE-cadherin ), and leukocyte TEM
Parfiniewicz et al., Acta Pol Pharm 2012
:
However,
TNF-alpha did not
cause such a significant increase in
sE-cadherin level