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PTBP1 — TSLP

Text-mined interactions from Literome

Soumelis et al., Nat Immunol 2002 (Dermatitis, Atopic) : We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c ( + ) dendritic cells (DCs) and induced production of the T ( H ) 2-attracting chemokines TARC ( thymus and activation regulated chemokine ; also known as CCL17 ) and MDC ( macrophage derived chemokine ; CCL22 )
Gilliet et al., J Exp Med 2003 (Hypersensitivity...) : Here, we show that TSLP activated CD11c+ DCs potently activate and expand naive CD8+ T cells, and induce their differentiation into interleukin (IL)-5 and IL-13 producing effectors exhibiting poor cytolytic activity
Soumelis et al., Springer Semin Immunopathol 2004 (Hypersensitivity...) : TSLP activated human DCs produce Th2 attracting chemokines but no IL-12, and induce naive CD4 ( + ) and CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Watanabe et al., Blood 2005 (Dermatitis, Atopic...) : We previously showed that human thymic stromal lymphopoietin (TSLP) , highly expressed by keratinocytes of atopic dermatitis, activates CD11c ( + ) DCs to induce the differentiation of naive CD4 ( + ) and CD8 ( + ) T cells into proallergic effectors
Ito et al., J Exp Med 2005 : We conclude that OX40L on TSLP activated DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10 producing regulatory Th cell responses into TNF-alpha producing inflammatory Th cell responses
Lin et al., Clin Immunol 2008 (Embryo Loss) : Thymic stromal lymphopoietin (TSLP)-TSLP receptor (TSLP-R) interactions activate CD11c ( + ) dendritic cells (DCs) and increase epithelial cell Th2-type cytokine production ... Murine recombinant TSLP activated DCs from BALB/c mice, with increased CD80 and CD83 expressions ; TSLP activated DCs induced IL-10 producing NK cell expansion
Lee et al., Immunol Cell Biol 2008 : Human thymic stromal lymphopoietin (TSLP) activates dendritic cells (DCs) , which promote the proliferation and differentiation of CD4+ T cells
Kamekura et al., Cell Tissue Res 2009 (Rhinitis, Allergic, Perennial) : The nasal-epithelial derived TSLP thus not only activates DCs but also preserves the epithelial barrier via the upregulation of tight-junction proteins, thereby regulating antigen sensitization during the early stage of allergic rhinitis
Li et al., J Asthma 2010 (Asthma...) : In the lung inflammation model, TSLP activates dendritic cells (DCs) via up-regulation of CD40, CD80, and CD86, then induces the differentiation of prime naive CD4 ( + ) T cells to become proinflammatory Th2 cells
Sugimoto et al., Clin Immunol 2010 : While BCG stimulated DCs induced CD8 ( + ) T cell production of IFN-gamma without strong cell expansion, TSLP stimulated DCs induced robust CD8 ( + ) T cell expansion without high quantities of IFN-gamma production
De Monte et al., J Exp Med 2011 (Pancreatic Neoplasms) : TSLP containing supernatants from activated CAFs induced in vitro myeloid DCs to up-regulate the TSLP receptor (TSLPR) , secrete Th2 attracting chemokines, and acquire TSLP dependent Th2 polarizing capability in vitro
Zhao et al., Cell Physiol Biochem 2012 (Atherosclerosis...) : Thymic stromal lymphopoietin (TSLP) can activate DCs and trigger adaptive immune responses
Chen et al., PloS one 2013 (Airway Remodeling...) : Thymic stromal lymphopoietin (TSLP) , an epithelium derived cytokine, can strongly activate lung dendritic cells (DCs) through the TSLP-TSLPR and OX40L-OX40 signaling pathways to promote Th2 differentiation