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NOS2 — RNF19A

Text-mined interactions from Literome

Chen et al., Mol Pharmacol 1999 : p38 but not p44/42 mitogen activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
Ajizian et al., J Infect Dis 1999 : Specific inhibitors of p38 and extracellular signal regulated kinase mitogen activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma
Feng et al., J Immunol 1999 : We now show that the extracellular signal related kinase ( ERK ) and p38 mitogen activated protein ( MAP ) kinases play differential roles in the regulation of LPS stimulated inducible NO synthase and IL-12 gene expression
Floyd et al., Proc Soc Exp Biol Med 1999 (Alzheimer Disease...) : iNOS induction involves activation by phosphorylation of the MAP kinase p38 and can be induced in cultured astrocytes by IL-1beta or H2O2
Liu et al., J Cell Biochem 2001 : We investigated the role of p38 MAP kinase activation and IkappaB phosphorylation in iNOS expression in a novel iNOS inducing model in mouse macrophages ... SB203580, however, did not prevent the phosphorylation of Akt and IkappaB, suggesting that the p38 MAP kinase signal contributes to iNOS gene expression through an IkappaB-phosphorylation independent pathway
Lin et al., Life Sci 2001 (Glioma...) : The tyrosine kinase inhibitor ( genistein and tyrphostin ), the Ras-farnesyl transferase inhibitor ( FPT inhibitor-II ), or the p38 MAPK inhibitor ( SB203580 ) suppressed AGEs induced iNOS expression and nitrite release from C6 glioma cells ... Taken together, our data suggest that AGEs may activate the pathways of tyrosine kinase and Ras to induce p38 MAPK activation, which in turn induces iNOS expression and NO production in C6 glioma cells
Monier et al., J Infect Dis 2002 : Differential effects of p38- and extracellular signal regulated kinase mitogen activated protein kinase inhibitors on inducible nitric oxide synthase and tumor necrosis factor production in murine macrophages stimulated with Streptococcus pneumoniae
Chong et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Increased p38 signaling may be responsible for the increased iNOS expression in SOCS-1-/- islets
Guo et al., Di Yi Jun Yi Da Xue Xue Bao 2003 : Regulation of inducible nitricoxide synthase gene transcription by p38 mitogen activated protein kinase in human embryonic kidney 293 cells
Ho et al., Br J Pharmacol 2004 (Inflammation) : The selective p38 MAPK inhibitor, SB203580, inhibited the promoter activities of iNOS and COX-2 rather than that of TNF-alpha
Won et al., Free Radic Biol Med 2004 : Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability
Chen et al., Pharmacol Res 2005 (Glioma...) : Taken together, our data suggest that chloroquine may activate tyrosine kinase and/or PKC to induce p38 MAPK activation, which in turn induces iNOS expression and NO production
Vega-Ostertag et al., Arthritis Rheum 2005 : Phosphorylation of p38 MAPK and induction of iNOS were determined by Western blotting, and levels of IL-6 and IL-8 were determined by ELISA
Vera et al., Mol Endocrinol 2006 : Initiation of germ cell apoptosis was preceded by p38 MAPK activation and induction of iNOS ... p38 MAPK activation and iNOS induction were further accompanied by a marked perturbation of the BAX/BCL-2 rheostat, cytochrome c, and DIABLO release from mitochondria, caspase activation, and poly ( ADP-ribose ) polymerase cleavage
Jeon et al., J Ethnopharmacol 2006 : KIOM-79 inhibits LPS induced iNOS gene expression by blocking NF-kappaB/Rel and p38 kinase activation in murine macrophages
Otero et al., Life Sci 2007 : Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
Ding et al., Free Radic Biol Med 2008 : Little is known about regulation of iNOS by As ( III ) and further investigations indicated that p38 mitogen activated protein kinase ( p38 MAPK ) and NF-kappaB are required for As ( III ) induction of iNOS expression
Ou et al., J Appl Physiol 2013 : In addition, exposure to oxLDL resulted in reduced AMPK mediated Akt/endothelial nitric oxide ( NO ) synthase signaling and the induction of phosphorylation of p38 mitogen activated protein kinase, which, in turn, activated NF-?B mediated inflammatory responses, such as the release of interleukin-8, the expression of the adhesion molecule, and the adherence of monocytic cells to human umbilical vein endothelial cells