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GNRH1 — IGF1
Text-mined interactions from Literome
Bourguignon et al., Brain Res 1999
:
We showed previously that
insulin-like growth factor-I (IGF-I) could
inhibit the secretion of
gonadotrophin releasing hormone (GnRH) evoked in vitro by N-methyl-D-aspartate ( NMDA ) or veratridine depolarization ... That effect was developmentally regulated since
IGF-I could
inhibit GnRH secretion from hypothalamic explants of 50-day-old adult rats but not from immature 15-day-old explants
Daftary et al., Endocrinology 2003
:
To better understand the regulation of GnRH neurons by hypothalamic IGF-1, we quantified levels of IGF-1 mRNA in hypothalamic and preoptic regions containing GnRH cells, studied the
effects of
IGF-1 on
GnRH gene expression, and examined the neuroanatomical relationship between GnRH neurons and hypothalamic IGF-1 in neonatal, peripubertal, and reproductively mature mice ... In contrast,
IGF-1 had no effect or even
inhibited GnRH gene expression in adult P60 mice
Dees et al., J Stud Alcohol 2005
:
Furthermore, as alcohol ( ALC ) blocks
IGF-1 induced
LHRH and LH release acutely, we aimed to determine if it could affect the ability of IGF-1 to stimulate Oct 2 gene expression
Pine et al., Reprod Toxicol 2006
(Prenatal Exposure Delayed Effects...) :
Because prepubertal female rats maternally exposed to lead ( Pb ) exhibit suppressed serum levels of insulin-like growth factor-1 (IGF-1) and delayed puberty, we investigated the ability of centrally administered
IGF-1 to
stimulate luteinizing hormone ( LH ) release in vivo and
LH-releasing hormone (LHRH) release in vitro from maternally Pb-exposed prepubertal female rats ... These results indicate the central
LHRH response to IGF-1 is intact and that Pb-induced delayed puberty is
due , at least in part, to suppressed circulating
IGF-1 available to the hypothalamus
Liu et al., Zhonghua Nan Ke Xue 2007
:
IGF-1 can
stimulate the expression of
GnRH gene in the hypothalamus of prepubertal male mice
Hiney et al., Neuroendocrinology 1991
:
The results demonstrate that IGF-I has the capability to act directly upon the median eminence to effect release of LHRH, thereby suggesting a
role for
IGF-I in facilitating peripubertal changes in
LHRH release
Luckenbach et al., Gen Comp Endocrinol 2010
:
Three experiments were conducted with dispersed pituitary cells of prepubertal male coho salmon ( Oncorhynchus kisutch ) to determine the time course of the response to IGF1,
IGF1 concentration
response , and
GnRH concentration response
Hiney et al., Neuroscience 2010
:
Since alcohol ( ALC ) blocks
IGF-1 induced
LHRH release acutely, we assessed whether this drug could affect IGF-1 stimulated prepubertal KiSS-1 gene expression following a binge type of exposure
Sun et al., Endocrinology 2011
:
Differential
effects of hypothalamic
IGF-I on
gonadotropin releasing hormone neuronal activation during steroid induced LH surges in young and middle aged female rats ... The present study investigated potential mechanisms by which
IGF-I receptors in the neuroendocrine hypothalamus
regulate GnRH neuronal activation and LH release in young and middle aged female rats under estradiol ( E2 ) positive feedback conditions ... These findings indicate that brain
IGF-I receptors are
required for E2 activation of GnRH neurons in young rats and for robust
GnRH release from axon terminals in middle aged females
Kaneko et al., Diabetes 1985
(Body Weight...) :
There were no differences in serum insulin-like growth factor I (IGF-I) levels between group 1 ( 262 +/- 35 ng/ml ) and group 2 ( 232 +/- 30 ng/ml ), and no significant correlation was found between serum
IGF-I levels and GH
responses to
GRH in either of the two groups
Sato et al., Endocrinology 1993
(Dwarfism) :
The
roles of GH and
insulin-like growth factor-I (IGF-I) in the regulation of hypothalamic
GH-releasing hormone (GRH) and somatostatin ( SRIH ) gene expression were investigated in the GH-deficient dwarf ( dw ) rat, in which endogenous feedback signals are lacking
Bourguignon et al., Endocrinology 1994
:
Growth Hormone Releasing Factor (GRF),
Insulin-like Growth Factor-I (IGF-I) and Proinsulin
result in inhibition of
GnRH secretion ... Protease inhibitors prevent the inhibitory
effects of
IGF-I on
GnRH secretion
Zhen et al., Mol Endocrinol 1997
:
Regulation of
gonadotropin releasing hormone (GnRH) gene expression by
insulin-like growth factor I in a cultured GnRH expressing neuronal cell line ... A GnRH expressing neuronal cell line ( NLT ) was used to determine whether
insulin-like growth factor I (IGF-I) regulates
GnRH gene expression
Yamada et al., Endocr J 1997
(Acromegaly...) :
Therefore, 34 ( 87.1 % ) out of 39 patients who have been followed up longer than 6 months met the following stringent criteria at the time of the final follow-up : mean basal GH level < 3 ng/ml, a normal
IGF-1 level, and normal GH
response to TRH,
GnRH and oral glucose administration
Hiney et al., Life Sci 1998
:
Thus, we have investigated the effects of ETOH on
IGF-1 induced LH release in vivo, and on IGF-1
induced prostaglandin-E2 ( PGE2 ) and
LH-releasing hormone (LHRH) release in vitro from rats during the juvenile phase of development as well as from rats during the early stage of first proestrus ...
IGF-1 stimulated the release of PGE2 ( p < 0.001 ) and
LHRH ( p < 0.01 ) from the incubated nerve terminals in the absence of ETOH ; however, these effects were blocked by the presence of ETOH
Longo et al., Endocrinology 1998
:
We examined the
effects of the neurotrophic factor
insulin-like growth factor-I (IGF-I) on
GnRH gene expression and the mechanism for these changes ... Initially,
effects of
IGF-I on
GnRH gene expression were determined by ribonuclease protection assay ... The increase in
GnRH mRNA levels
induced by
IGF-I is probably caused by a transcriptional mechanism, as evidenced by the increase in GnRH primary transcript levels before a change in GnRH mRNA levels, as well as our finding of a similar GnRH mRNA half-life for both control and IGF-I treated cells
Marelli et al., Endocrinology 1999
(Prostatic Neoplasms) :
To this purpose, the
effects of the
LHRH agonist Zoladex (LHRH-A) on 1 ) the mitogenic action of IGF-I, 2 ) the tyrosine phosphorylation of type 1
IGF-I receptor (IGF-IR) , 3 ) the concentration of IGF-IR, and 4 ) the secretion of IGF binding protein-3 were studied