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EGF — SPHK2

Text-mined interactions from Literome

Hait et al., J Biol Chem 2007 : Down-regulation of ERK1 blocked EGF induced phosphorylation of SphK2
Martin et al., J Biol Chem 2009 : IGFBP-3 potentiated EGF stimulated EGF receptor activation and DNA synthesis, and this was blocked by inhibitors of SphK activity or small interference RNA mediated silencing of SphK1, but not SphK2, expression ... IGFBP-3 potentiated EGF stimulated EGF receptor activation and DNA synthesis, and this was blocked by inhibitors of SphK activity or small interference RNA mediated silencing of SphK1, but not SphK2 , expression
Kharel et al., Biochem J 2011 : However, SphK1 inhibition did diminish EGF ( epidermal growth factor ) -driven increases in S1P levels and Akt ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation
Rius et al., FEBS Lett 1997 (Pheochromocytoma) : In contrast, epidermal growth factor and insulin-like growth factor-1, which stimulate proliferation of PC12 cells, induced only small and transient increases in sphingosine kinase activity