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AHSA1 — IL12B
Text-mined interactions from Literome
Utsugi et al., J Immunol 2003
(MAP Kinase Signaling System) :
Inhibition of
p38 MAP kinase activation using SB203580 dose dependently
repressed LPS induced
IL-12 p40 production, as described
Zhu et al., J Biol Chem 2005
(Inflammation) :
Furthermore,
p38 is
critical for the production of IL-6 and
IL-12 but is only marginally required for the production of TNF-alpha and nitric oxide
Jarnicki et al., J Immunol 2008
(MAP Kinase Signaling System...) :
Inhibition of
p38 suppressed TLR induced IL-10 and PGE ( 2 ) and
enhanced IL-12 production in DC
Boucher et al., Viral Immunol 2010
(HIV Infections...) :
In primary monocytes, the inhibition of
p38 enhanced
IL-12 production, whereas it downregulated IL-12 production in THP-1 cells ... In THP-1 cells,
p38 , ERK, and JNK inhibition
increased NF-kappaB and Sp1 binding to the
IL-12p40 promoter, while inhibiting AP-1 binding
McBerry et al., J Immunol 2012
(Disease Models, Animal...) :
p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2
suppressed TLR induced
IL-12/23p40 production ...
p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2
suppressed TLR induced
IL-12/23p40 production