◀ Back to EPHB2

EPHB2 — PLAUR

Text-mined interactions from Literome

Aguirre Ghiso et al., J Cell Biol 1999 (MAP Kinase Signaling System...) : Disruption of uPAR-alpha5beta1 complexes in uPAR-rich cells with antibodies or a peptide that disrupts uPAR-beta1 interactions, reduced the FN-dependent ERK1/2 activation ... These results indicate that dormancy of low uPAR cells may be the consequence of insufficient uPA/uPAR/alpha5beta1 complexes, which can not induce ERK1/2 activity above a threshold needed to sustain tumor growth in vivo
Ossowski et al., Medicina (B Aires) 1999 (Neoplasm Invasiveness...) : We have shown that uPAR co-associates with fibronectin binding integrin, alpha 5 beta 1, activates them and that this interaction leads to a greatly increased level of active ERK
Webb et al., J Cell Biol 2001 (Breast Neoplasms) : The kinetics of ERK phosphorylation in response to uPAR ligation determine the function of uPA and uPA-PAI-1 complex as growth promoters
Ahmed et al., Br J Cancer 2003 (Colonic Neoplasms...) : Antisense inhibition of the cell surface expression of uPAR by 50 % in human colon carcinoma HCT116 cells ( A/S ) suppressed Erk-MAP kinase activity by two-fold
D'Alessio et al., Int J Cancer 2004 (Melanoma...) : Following aODN treatment, human melanoma cells exhibited a strong decrease of uPAR dependent ERK1/2 activation and were used in vivo to control metastasis in CD-1 male nude ( nu/nu ) mice by uPAR aODN injection
Marek et al., J Cell Physiol 2004 : Like NFLC, induction of urokinase plasminogen activator (uPAR) , transin/matrix metalloproteinase 3 (MMP3), Fra-1 and transforming growth factor beta 1 ( TGF beta 1 ) required collaborative ERK and JNK signaling while the increased expression of cortexin, rat collapsin response mediator protein 4 ( rCRMP4 ), rat growth and transformation dependent protein ( RGT ), and synapsin II required neither mitogen activated protein kinase ( MAPK ) pathway
Mazzieri et al., Mol Biol Cell 2006 : On the contrary, hcr-uPAR does not activate ERK and does not engage FPRL1 or any other G protein coupled receptor, but it activates an alternative pathway initiated by the formation of a triple complex ( uPAR-alpha3beta1-EGFR ) and resulting in the autotyrosine phosphorylation of EGFR
Yoon et al., Cell Res 2006 (Breast Neoplasms) : These results demonstrated that uPAR is induced by hypoxia and that increased uPAR expression is mediated by ERK phosphorylation, which in turn is modulated by iNOS/NO in MDA-MB-231 cells
Bessard et al., J Cell Physiol 2007 (Carcinoma, Hepatocellular...) : MEK/ERK dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells
Liu et al., Am J Physiol Cell Physiol 2008 : In a 3-D system, we found that not only uPA-uPAR association but also the activation of ERK were inhibited by HKa
Chaurasia et al., PloS one 2009 (Neoplasm Metastasis) : Disruption of uPAR/integrin interaction blocks ERK activation and forces cancer cells into dormancy ... Of these 68 chemical hits, ten inhibited ERK activation in a cellular assay and of those, 2 compounds, 2- ( Pyridin-2-ylamino ) -quinolin-8-ol and, 2,2'- ( methylimino ) di ( 8-quinolinol ) inhibited ERK activation by disrupting the uPAR/integrins interaction
Nalla et al., Cell Signal 2011 (Meningeal Neoplasms...) : Downregulation of uPA and uPAR , simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) inhibited radiation induced ERK activation, nuclear translocation of Rel-A, NF-?B DNA binding activity, and MCP-1 expression
Hu et al., Proc Natl Acad Sci U S A 2011 (Glioblastoma) : Here, we show that uPAR does not regulate ERK activation in EGFRvIII expressing GBM cells ; however, in GBM cells isolated from four separate xenografts in which EGFRvIII expression was down-regulated in vivo, uPAR assumed a major role in sustaining ERK activation
Whyte et al., J Nutr Biochem 2012 (MAP Kinase Signaling System) : We also showed that MEK/ERK pathway activation was involved in the regulation of uPAR gene expression in SMCs
Eastman et al., Cell Signal 2012 : Binding of urokinase-type plasminogen activator ( uPA ) to its receptor, uPAR , in estrogen receptor-a ( ERa ) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras ... Autonomous ERK activation by uPAR requires H-Ras and Rac1