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NR4A1 — PGF

Text-mined interactions from Literome

Stocco et al., J Biol Chem 2002 : In this report we established, using luteinized granulosa cells, that PGF ( 2alpha ) stimulates in vitro nur77 expression in a time- and dose dependent manner ... Serial 5'-deletion of the nur77 promoter revealed that the necessary and sufficient elements for PGF ( 2alpha ) induction of Nur77 promoter activity are located between the nucleotides -86 and -33 upstream of the transcription start site, this region containing two AP1 elements ... However, mutation of the AP1 sites as well as a dominant negative JunD abolished nur77 induction by PGF ( 2alpha )
Liang et al., Br J Pharmacol 2004 : Upregulation of orphan nuclear receptor Nur77 following PGF ( 2alpha ), Bimatoprost, and Butaprost treatments ... 3. We also used Nur77 as a marker gene to compare the effects of PGF ( 2alpha ), Butaprost, and Bimatoprost ( a prostamide ) on Nur77 expression in human primary trabecular meshwork and ciliary smooth muscle ( SM ) cells, which are target cells for antiglaucoma drugs ... PGF ( 2alpha ), but not Bimatoprost, dramatically induced upregulation of Nur77 mRNA expression in human ciliary SM cells, whereas Butaprost slightly upregulated Nur77 mRNA expression in SM cells