Jegalian et al., J Interferon Cytokine Res 2002
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Using two independent approaches, one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades, we demonstrate that induction of SOCS1, SOCS2 , SOCS3, and cytokine-inducible SH2 containing protein ( CIS ) in response to EPO stimulation appears to depend on Stat5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase (PI3K)
Kazi et al., Mol Oncol 2013
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SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5