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ITPR1 — TNF

Text-mined interactions from Literome

Park et al., J Biol Chem 2008 (Calcium Signaling...) : Herein, we describe a novel neuron-intrinsic pathway in which the expression of the type-1 inositol 1,4,5-trisphosphate receptor is regulated by the potent pro-inflammatory cytokine tumor necrosis factor-alpha
Park et al., J Biol Chem 2009 (Inflammation...) : Tumor necrosis factor-alpha mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter
Xia et al., FEBS Lett 2012 (Bone Resorption...) : We found that TNF-a increased the expression of IP3R1 and promoted osteoclastogenesis in RANKL induced mouse BMMs. Phosphatidylcholine-specific phospholipase C ( PC-PLC ) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-a, and decreased the autoamplification of nuclear factor of activated T-cells 1 ( NFATc1 ), thus resulted in less osteoclasts formation