◀ Back to RAC1
ARHGDIA — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GDP complex (RAC1)
→
RHOGDI (ARHGDIA)
(modification, collaborate)
Sasaki et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
Evidence: assay
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GDP complex (RAC1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
Sasaki et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
Evidence: assay
-
NCI Pathway Database Regulation of RAC1 activity:
RHOGDI (ARHGDIA)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
Sasaki et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
Evidence: assay
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GDP complex (RAC1)
→
RHOGDI (ARHGDIA)
(modification, collaborate)
Hart et al., J Biol Chem 1994, Yaku et al., Biochem Biophys Res Commun 1994*
Evidence: assay, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
RHOGDI (ARHGDIA)
→
RAC1/GDP complex (RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database RAC1 signaling pathway:
RHOGDI (ARHGDIA)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GDP complex (RAC1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database RAC1 signaling pathway:
PAK1 (PAK1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, activates)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
RHOGDI (ARHGDIA)
→
RAC1/GDP complex (RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
RHOGDI (ARHGDIA)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
RAC1/GDP complex (RAC1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
PAK1 (PAK1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, activates)
DerMardirossian et al., Mol Cell 2004*
Evidence: assay
-
NCI Pathway Database Regulation of RAC1 activity:
RHOGDI (ARHGDIA)
→
RAC1/GTP complex (RAC1)
(modification, collaborate)
Chuang et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of RAC1 activity:
RHOGDI (ARHGDIA)
→
RAC1/GTP/RHOGDI complex (RAC1-ARHGDIA)
(modification, collaborate)
Chuang et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GTP complex (RAC1)
→
RAC1/GTP/RHOGDI complex (RAC1-ARHGDIA)
(modification, collaborate)
Chuang et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
Evidence: assay, physical interaction
-
NCI Pathway Database CDC42 signaling events:
RHOGDI (ARHGDIA)
→
RAC1/GDP complex (RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: mutant phenotype, assay
-
NCI Pathway Database CDC42 signaling events:
RHOGDI (ARHGDIA)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: mutant phenotype, assay
-
NCI Pathway Database CDC42 signaling events:
RAC1/GDP complex (RAC1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, collaborate)
DerMardirossian et al., Mol Cell 2004*
Evidence: mutant phenotype, assay
-
NCI Pathway Database CDC42 signaling events:
PAK1 (PAK1)
→
RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1)
(modification, activates)
DerMardirossian et al., Mol Cell 2004*
Evidence: mutant phenotype, assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(physical association, affinity chromatography technology)
Yu et al., J Biol Chem 2012*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(direct interaction, two hybrid)
Vinayagam et al., Science signaling 2011
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(physical association, affinity chromatography technology)
Ewing et al., Molecular systems biology 2007
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(association, x-ray crystallography)
Lian et al., Structure 2000*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(direct interaction, pull down)
Grizot et al., Biochemistry 2001*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(association, x-ray crystallography)
Grizot et al., Biochemistry 2001*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(association, biochemical)
Gorvel et al., FEBS Lett 1998*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(direct interaction, two hybrid)
Fauré et al., Biochimie 2001*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(direct interaction, two hybrid)
Di-Poï et al., Biochemistry 2001*
-
IRef Biogrid Interaction:
ARHGDIA
—
RAC1
(association, biochemical)
Di-Poï et al., Biochemistry 2001*
-
IRef Hprd Interaction:
ARHGDIA
—
RAC1
(two hybrid)
Newcombe et al., Biochemistry 1999*, Lian et al., Structure 2000*, Di-Poï et al., Biochemistry 2001*
-
IRef Hprd Interaction:
ARHGDIA
—
RAC1
(in vivo)
Newcombe et al., Biochemistry 1999*, Lian et al., Structure 2000*, Di-Poï et al., Biochemistry 2001*
-
IRef Hprd Interaction:
ARHGDIA
—
RAC1
(in vitro)
Newcombe et al., Biochemistry 1999*, Lian et al., Structure 2000*, Di-Poï et al., Biochemistry 2001*
-
IRef Intact Interaction:
RAC1
—
ARHGDIA
(direct interaction, x-ray crystallography)
Grizot et al., Biochemistry 2001*
-
IRef Intact Interaction:
RAC1
—
ARHGDIA
(physical association, anti bait coimmunoprecipitation)
Ewing et al., Molecular systems biology 2007
-
IRef Intact Interaction:
RAC1
—
ARHGDIA
(physical association, pull down)
ten Klooster et al., EMBO J 2007*
-
IRef Intact Interaction:
RAC1
—
ARHGDIA
(physical association, two hybrid)
Vinayagam et al., Science signaling 2011
-
IRef Intact Interaction:
RAC1
—
ARHGDIA
(physical association, pull down)
Navarro-Lérida et al., EMBO J 2012*
-
IRef Intact Interaction:
RAC1
—
ARHGDIA
(physical association, anti tag coimmunoprecipitation)
Navarro-Lérida et al., EMBO J 2012*
-
IRef Ophid Interaction:
RAC1
—
ARHGDIA
(aggregation, confirmational text mining)
Lian et al., Structure 2000*
-
IRef Ophid Interaction:
RAC1
—
ARHGDIA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Qi et al., Cardiovasc Res 2008
:
A decrease in
Rho-GDIalpha expression by using target small interfering RNA ( siRNA ) transfection
caused increases in the phosphorylation of
Rac1 and Akt and enhancements of VSMC migration and apoptosis
Dovas et al., J Biol Chem 2010
:
Here, it is demonstrated that conventional PKC phosphorylates
RhoGDIalpha on serine 34,
resulting in a specific decrease in affinity for RhoA but not
Rac1 or Cdc42