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IRAK4 — JUN

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 2001 : Mutant I1A cells, lacking IL-1 receptor associated kinase (IRAK) mRNA and protein, have been used to study the involvement of IRAK in NFkappaB and c-Jun N-terminal kinase (JNK) activation
Dolganiuc et al., Gastroenterology 2004 (Hepatitis C...) : HCV core and NS3 induced interleukin (IL)-1 receptor associated kinase ( IRAK ) activity, phosphorylation of p38, extracellular regulated ( ERK ), and c-jun N-terminal ( JNK ) kinases and induced AP-1 activation
Chandrasekar et al., J Biol Chem 2005 : Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression
Song et al., Mol Immunol 2009 (Inflammation) : In contrast, an inhibitor of both IRAK-1 and IRAK-4 ( RO0884 ) reduced IL-1beta induced p38 MAP kinase, c-Jun N-terminal kinase activation, and IL-6 production in HUVEC
Merry et al., J Heart Lung Transplant 2010 (Lung Injury...) : Lungs were assessed for vascular permeability, myeloperoxidase content, bronchoalveolar lavage inflammatory cell and cytokine/chemokine content, as well as nuclear translocation of nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1) , and interleukin-1 receptor associated kinase-1 ( IRAK-1 ) and stress activated protein kinase ( SAPK ) activation
Yang et al., J Ethnopharmacol 2013 : In addition, the observed downregulation of activator protein (AP)-1 and cAMP response element binding ( CREB ) was due to the direct inhibition of interleukin-1 receptor associated kinase ( IRAK)1 and IRAK4, which was also linked to the suppression of c-Jun N-terminal kinase (JNK) and p38