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IL4 — PTGS2

Text-mined interactions from Literome

Alaaeddine et al., Arthritis Rheum 1999 (Osteoarthritis) : IL-4 , IL-10, and IL-13 reduced the TNFalpha induced COX-2 level, and IL-4 and IL-10 reduced the cPLA2 level
Keelan et al., Prostaglandins Leukot Essent Fatty Acids 1999 : Immunoblotting studies revealed that IL-4 ( 10 ng/ml ) significantly suppressed prostaglandin-H synthase-2 (PGHS-2) levels in cells stimulated with IL-1beta and TNF-alpha over 16 h, but had no consistent effects on cytosolic phospholipase A2 (cPLA2) levels under any condition
Fosslien et al., Ann Clin Lab Sci 2000 (Carcinoma, Squamous Cell...) : COX-2 is inducible by oncogenes ras and scr, interleukin-1 , hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha
Hayashi et al., Cytokine 2000 : These results indicate that IL-1beta induced delayed PGE ( 2 ) generation in these human fibroblasts mainly depends on de novo induction of COX-2 and cPLA(2), irrespective of the constitutive presence of COX-1, and that IFN-gamma and IL-4 inhibit IL-1beta induced delayed PGE ( 2 ) generation by suppressing, predominantly, COX-2 expression
Kitamura et al., Eur J Pharmacol 2001 : These results suggest that the response to lipopolysaccharide is partially dependent on Toll-like receptor-4 in mouse glial cells, and that 15-deoxy-Delta ( 12,14 ) prostaglandin J ( 2 ) and interleukin-4 differently regulate the expression of inducible NO synthase and cyclooxygenase-2 , and heme oxygenase-1
Nédélec et al., Biochem Pharmacol 2001 : In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Nagano et al., Int Immunol 2002 : Since we previously showed that IL-10 and IL-4 similarly inhibited COX-2 expression in LPS stimulated neutrophils, we next tested the effects of IL-10 and IL-4 on the phosphorylation and activation of both kinases
Soloff et al., Endocrinology 2004 : In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells
Inoue et al., J Immunol 2004 (MAP Kinase Signaling System) : Both IL-10 and IL-4 significantly inhibited PGE ( 2 ) production and COX-2 expression in CD40 stimulated monocytes
Stamp et al., J Rheumatol 2004 : Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes : role of interleukin 17 and interferon-gamma
Bian et al., Proc Natl Acad Sci U S A 2005 : We now demonstrate that ( i ) an IL-4 receptor alpha-subunit ( IL-4Ralpha ) /Stat6 dependent but T cell independent pathway is the key for the nematode induced host NOS-2 inhibition ; ( ii ) endogenous IL-4 and IL-13, the only known IL-4Ralpha ligands, are not required for activating the pathway ; and ( iii ) treatment of RAW264.7 cells with parasite cultured medium inhibits NOS-2 expression but not cyclooxygenase 2 expression
Attar et al., Hum Reprod Update 2006 (Endometriosis...) : COX-2 in turn is stimulated by E ( 2 ), interleukin-1beta (IL-1beta) and PGE ( 2 ) itself in endometrial and endometriotic cells
Cui et al., Biochem Biophys Res Commun 2006 (Carcinoma, Non-Small-Cell Lung...) : IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer ... We found that IL-4 inhibited constitutive COX-2 expression and PGE ( 2 ) production in A427 and H2122 NSCLC cell lines, and also suppressed IL-1beta induced COX-2 expression in A549 and RH2 NSCLC cell lines ... COX-2 mRNA was decreased in response to IL-4, and promoter analysis indicated that IL-4 inhibited both constitutive and IL-1beta induced COX-2 transcription
Teloni et al., Immunology 2007 : Interleukin-4 inhibits cyclo-oxygenase-2 expression and prostaglandin E production by human mature dendritic cells ... In this study we demonstrate that IL-4 inhibits COX-2 gene expression and consequently prevents secretion of PGE ( 2 ) by mature human dendritic cells
Wu et al., Prostaglandins Other Lipid Mediat 2007 : In this review, we provide evidence for reduced COX-2 transcriptional expression in response to phorbol esters ( PMA ), lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)
Wu et al., Reprod Sci 2007 (Endometriosis) : These results, along with recent findings that TSA suppresses proliferation, interleukin-1 beta induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
Yao et al., Inflamm Res 2010 : Moreover, NF-kappaB p50, COX-2 , and iNOS levels in SF were markedly suppressed by AD-IL-18BP/IL-4 ... AD-IL-18BP/IL-4 can suppress the production and expression of inflammatory cytokines such as COX-2 , iNOS, and NF-kappaB in LPS stimulated SF
Vinukonda et al., Brain 2010 (Disease Models, Animal...) : Cyclooxygenase-2 or prostanoid receptor-1 inhibition reduced tumour necrosis factor-a level, but not interleukin-1ß
Cho et al., Mol Immunol 2011 : Knocking down JAK1 and STAT6 ablated the inhibitory effect of IL-4 on COX-2 expression and significantly reduced production of PGE ( 2 ) and prostacyclin
Macedo et al., Inflammation 2012 (Cystitis...) : Exogenous IL-4 also attenuated TNF-a, IL-1ß, iNOS, and COX-2 expressions in ifosfamide treated bladders
Martín et al., J Hypertens 2012 : This study analyzes the effect of pioglitazone, a PPAR? agonist, on interleukin-1ß induced COX-2 expression and the role of reactive oxygen species ( ROS ) on this effect ... PPAR? activation with pioglitazone reduces interleukin-1ß induced COX-2 expression by interference with the redox-sensitive transcription factor NF-?B
Steinke et al., Journal of allergy 2012 : IL-4 can inhibit basal and stimulated expression of COX-2 and microsomal PGE synthase 1 leading to decreased capacity for PGE ( 2 ) secretion
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Obermajer et al., Transplantation research 2012 : We observed that PGE2 induces endogenous cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra , nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
Cho et al., Immune network 2013 : Both IL-4 and HDAC inhibitors suppressed COX-2 expression in dose dependent manners ... Our results suggest that IL-4 may regulate COX-2 expression in FDCs by affecting chromatin remodeling and provide insight into the role of cellular interactions between T cells and FDC during the GC reaction
Murakami et al., Proc Natl Acad Sci U S A 1995 : Interleukin 4 suppresses c-kit ligand induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow derived mast cells ... IL-4 inhibited the induction of PGHS-2 expression and the accompanying cytokine initiated delayed PGD2 generation with an IC50 of approximately 6 ng/ml. IL-4 had no effect on the expression of PGHS-2 and the production of PGD2 elicited by addition of IL-1 beta to the combination of KL + IL-10
Niiro et al., Blood 1995 : IL-10 and IL-4 significantly inhibited LPS induced COX-2 expression
Szczepanski et al., Arthritis Rheum 1994 : Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1
Feng et al., Arch Biochem Biophys 1993 : In rat vascular smooth muscle cells, interleukin-1 beta selectively increased the expression of COX-2 , but not that of COX-1, as assessed by enzyme activity, immunoprecipitation of COX proteins, and mRNA analysis
Onoe et al., J Immunol 1996 (Bone Resorption) : Both IL-13 and IL-4 dose-dependently suppressed the IL-1 alpha induced stimulation of both COX-2 mRNA expression and PGE2 synthesis
Spaziani et al., Prostaglandins 1996 (Obstetric Labor, Premature) : The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4 ... Our data suggest that the cytokine IL-4 may be involved in the pathogenesis of premature labor by inducing COX-2 in amnion tissue resulting in increased production of PGE2 and subsequent myometrial activity
Crofford et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
Niiro et al., Blood 1997 : Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils
Harding et al., Biochim Biophys Acta 1996 : These results indicate that regulation of interleukin-1beta stimulated prostaglandin E2 synthesis by interferons and interleukin-4 is controlled at the m-RNA level of cyclooxygenase-2
Kniss et al., Am J Obstet Gynecol 1997 : Interleukin-1 receptor antagonist blocks interleukin-1 induced expression of cyclooxygenase-2 in endometrium ... Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress interleukin-1 induced cyclooxygenase-2 expression
Lantz et al., Am J Obstet Gynecol 1998 : The induction of cyclooxygenase-2 by interleukin-4 in human umbilical vein endothelial cells : a possible role in regulation of fetal vascular tone
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Endo et al., Am J Respir Cell Mol Biol 1998 : Western and Northern blot analyses revealed that the LPS induced increases in COX-2 protein and mRNA were attenuated by IL-4 but hardly affected by IL-10, IL-13 or IFN-gamma ... IL-4 , IL-10, and IL-13 significantly suppressed LPS dependent PGE2 synthesis and COX-2 mRNA induction in monocytes, whereas only IL-4 significantly suppressed them in AM
Niiro et al., Biochem Biophys Res Commun 1998 : Since we previously showed that interleukin (IL)-10 and IL-4 similarly inhibited COX-2 expression in LPS stimulated monocytes, we next questioned whether these cytokines regulate the phosphorylation and activation of ERK2 and p38 MAPK in LPS stimulated monocytes
Longo et al., Mediators Inflamm 1998 : The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation