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IL13 — STAT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of STAT1-STAT1 → IL13 (increases) Doucet et al., Oncogene 2000*
  Evidence: In Figure 6a ± c (upper blots), STAT1a was tyrosine phosphorylated in response to IL-4 and IL-13 in both ®broblasts and myo®broblasts, as shown by the appearance of a single band of about 160 kD...Indeed, phosphorylation and dimerization of STAT1 (homo or heterodimers) occurred within 1 min follow- ing IL-4 or IL-13-stimulation and increased up to 30 min (Figure 6a,b, upper blots).
• OpenBEL Selventa BEL large corpus: STAT1 → IL13 (increases) Doucet et al., Oncogene 2000*
  Evidence: In Figure 6a ± c (upper blots), STAT1a was tyrosine phosphorylated in response to IL-4 and IL-13 in both ®broblasts and myo®broblasts, as shown by the appearance of a single band of about 160 kD...Indeed, phosphorylation and dimerization of STAT1 (homo or heterodimers) occurred within 1 min follow- ing IL-4 or IL-13-stimulation and increased up to 30 min (Figure 6a,b, upper blots).

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999 : Interestingly, interleukin (IL)-7 selectively activated STAT1 and induced MHC class I in mature T but not B cells
Xu et al., Mol Cell Biol 2003 : Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen activated protein kinase mediated serine 727 phosphorylation of Stat1 and Stat3 ... We found that IL-13 induced a time dependent serine phosphorylation of both Stat1 and Stat3, detectable at 15 min after IL-13 treatment ... SB202190, a p38 MAPK-specific inhibitor, markedly inhibited IL-13 induced Stat1 and Stat3 serine phosphorylation as well as DNA binding
Wang et al., Mol Immunol 2004 : STAT-1 is activated by IL-4 and IL-13 in multiple cell types
Chiba et al., J Smooth Muscle Res 2009 (Asthma...) : As a result, ut was found that both IL-13 and IL-4 caused a significant increase in the levels of phosphorylated STAT1
Bhattacharjee et al., Free Radic Biol Med 2013 : We further show that Jak2 is upstream of Stat3 activation and Tyk2 controls Stat1 and Stat6 activation in response to IL-13 stimulation
Murata et al., J Immunol 1996 (Colonic Neoplasms) : Both IL-13 and IL-4 induced phosphorylation of IL-4 STAT ( STAT6 ) but not STAT1 , STAT3, or STAT5