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FMR1 — TNF

Text-mined interactions from Literome

Tong et al., Zhonghua Jie He He Hu Xi Za Zhi 2003 (Sarcoidosis, Pulmonary) : It was investigated that the effects of POF on the production of TNF-alpha , interleukin (IL)-1beta, IL-6, IL-8, IL-10 and the soluble TNF-alpha receptors ( sTNFR-1 and sTNFR-2 ) from AM in sarcoidosis, as comparison to dexamethasone ( DEX ) ... POF induced a dose dependent suppression of the spontaneous TNF-alpha release from AM in sarcoidosis ( P < 0.001 ), while the spontaneous release of other cytokines was unaffected by POF at all tested concentrations, but a trend for the inhibition of IL-10 production was found ( P = 0.092 )
Tong et al., Chest 2003 (Sarcoidosis, Pulmonary) : In this study, we aimed to investigate the effects of POF on the production of TNF-alpha , interleukin (IL)-1 beta, IL-6, IL-8, IL-10, and the soluble TNF receptors ( sTNFRs ) 1 and 2 from AMs in sarcoidosis, and we also compared them with those of dexamethasone ( DEX ) ... The results showed that POF induced a dose dependent suppression of the spontaneous TNF-alpha release from AMs in sarcoidosis ( p < 0.001 ), and that the spontaneous release of the other cytokines was unaffected by POF at all tested concentrations, but a trend for the inhibition of IL-10 production was found ( p = 0.092 )
Tong et al., Zhonghua Yi Xue Za Zhi 2004 (Alveolitis, Extrinsic Allergic) : To investigate the effects of POF on the production of tumor necrosis factor (TNF) alpha , interleukin (IL)-1beta, IL-6, IL-8, IL-10 and the soluble TNF receptors ( sTNFR1 and sTNFR2 ) from AM in EAA, also in comparison with dexamethasone ( DEX ) ... POF induced a dose dependent suppression of spontaneous TNFalpha and IL-10 release from AM in EAA ( P < 0.001 and P < 0.05 )
Duman et al., Dig Dis Sci 2007 (Disease Progression...) : This study was designed to investigate the effect of POF on TNF-alpha production by peripheral blood mononuclear cells ( PBMC ) in patients with NASH ... In this LPS stimulated culture system, POF caused a dose dependent suppression of TNF-alpha levels ( P < 0.001, ANOVA on ranks for repeated measures ) ... At 500 microg/ml, POF suppressed TNF-alpha production to levels significantly lower than that obtained in unstimulated ( baseline ) culture supernatants ( 76.3 ( range, 33-94.5 ) pg/ml ; P = 0.001 )
Schade et al., Circ Shock 1990 (Shock, Septic) : POF was found to inhibit the appearance of TNF in serum of LPS treated, D-galactosamine sensitized mice and in the supernatants of LPS stimulated, thioglycollate induced mouse peritoneal macrophages
Körber et al., Immun Infekt 1995 (Sarcoidosis) : We could demonstrate that POF ( above 4.10 ( -4 ) M ) inhibited the secretion of superoxide anion and TNF-alpha by AM in a dose dependent manner via a prostaglandin synthesis dependent mechanism that was independent of the glucocorticoid receptor
Brzychcy et al., Zentralbl Bakteriol 1997 (Disease Models, Animal...) : The course of L. monocytogenes infection was followed in mice treated with pentoxifylline (POF) , a known inhibitor of endogenous tumor necrosis factor (TNF) formation
Hemmer et al., Am J Trop Med Hyg 1997 (Malaria, Falciparum...) : To test whether POF affects TNF alpha serum levels or other variables in this disease, we administered POF ( 20 mg/kg/day intravenously in 150 ml of saline for five days ) randomized versus placebo ( 150 ml of saline without POF ) in addition to standard antimalarial therapy
Marques et al., Am J Respir Crit Care Med 1999 (Sarcoidosis, Pulmonary) : The aim of this study was to investigate whether POF induced suppression of TNF-alpha secretion affects peripheral blood monocytes ( PBM ) and alveolar macrophages ( AM ) equally, and whether POF is able to suppress the spontaneous TNF-alpha production from AM in pulmonary sarcoidosis in vitro ... In six patients with sarcoidosis we investigated the effect of POF on the enhanced spontaneous TNF-alpha production by AM in vitro ... POF induced a dose dependent suppression of the LPS stimulated TNF-alpha production which was not different for PBM and AM, respectively ... In sarcoidosis, POF inhibited the spontaneous TNF-alpha production of AM at 0.1 mM by 91 % and at 1 mM by 98 % ... In conclusion, POF inhibits LPS induced TNF-alpha production from PBM and AM to a similar extent and can also inhibit the exaggerated spontaneous TNF-alpha production from AM in sarcoidosis in vitro