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SMURF1 — TNF

Text-mined interactions from Literome

Kaneki et al., J Biol Chem 2006 : We treated C2C12 and 2T3 osteoblast precursor cell lines and primary osteoblasts with TNF and found that TNF , but not interleukin-1, significantly increased Smurf1 and Smurf2 expression
Guo et al., J Biol Chem 2008 (Inflammation) : We conclude that in chronic inflammatory disorders where TNF is increased, TNF induces the expression of ubiquitin ligase Smurf1 and promotes ubiquitination and proteasomal degradation of Smad1 and Runx2, leading to systemic bone loss
He et al., PloS one 2012 (Inflammation...) : TNF-a also induces the expression of E3 ubiquitin ligase protein Smurf1 and Smurf2 and promotes degradation of Runx2, another key transcription factor regulating osteoblast differentiation and bone formation
Lee et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Here, we investigated the molecular mechanism by which TNF-a stimulates Smurf1 expression in C2C12 and primary cultured mouse calvarial cells ... Smurf1 induction by TNF-a was blocked by the inhibition of JNK or ERK, while the inhibition of NF-?B and p38 MAPK had no effect on Smurf1 induction ... Site directed mutagenesis of the Smurf1 reporter and chromatin immunoprecipitation analysis demonstrated that the activating protein-1 (AP-1) binding motif at -922 bp on the mouse Smurf1 promoter mediated TNF-a/JNK/AP-1 stimulated Smurf1 transcription ... When Runx2 was ectopically expressed in these cells, the basal and TNF-a induced expression of Smurf1 was restored