Gene interactions and pathways from curated databases and text-mining

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PIAS4 — TCF4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ihara et al., Mol Cell Biol 2005 : SUMO-1 modification of PIASy , an E3 ligase, is necessary for PIASy dependent activation of Tcf-4 ... PIASy ( K35R ) could not stimulate the transcriptional activity of Tcf-4 under the conditions in which wild-type PIASy enhanced it
Hikata et al., Blood 2009 : Interestingly, PIAS3 inhibits the transcriptional activity of microphthalmia associated transcription factor ( MITF ) independent of sumoylation