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NEDD8 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: FBXO11 (FBXO11) → p53/NEDD8 complex (TP53-NEDD8) (modification, activates)
  Abida et al., J Biol Chem 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: p53 (TP53) → NEDD8 (NEDD8) (modification, collaborate) Abida et al., J Biol Chem 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: p53 (TP53) → p53/NEDD8 complex (TP53-NEDD8) (modification, collaborate)
  Abida et al., J Biol Chem 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: NEDD8 (NEDD8) → p53/NEDD8 complex (TP53-NEDD8) (modification, collaborate)
  Abida et al., J Biol Chem 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: p53 (TP53) → NEDD8 (NEDD8) (modification, collaborate) Xirodimas et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: p53 (TP53) → p53/NEDD8 complex (TP53-NEDD8) (modification, collaborate)
  Xirodimas et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: NEDD8 (NEDD8) → p53/NEDD8 complex (TP53-NEDD8) (modification, collaborate)
  Xirodimas et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: MDM2 (MDM2) → p53/NEDD8 complex (TP53-NEDD8) (modification, activates)
  Xirodimas et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Loftus et al., EMBO Rep 2012*
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Leidecker et al., Cell cycle (Georgetown, Tex.) 2012*
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Xirodimas et al., Cell 2004*
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Carter et al., Nat Cell Biol 2007*
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Yang et al., Oncogene 2007*
• IRef Biogrid Interaction: NEDD8 — TP53 (direct interaction, pull down) Abida et al., J Biol Chem 2007
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Li et al., Arch Biochem Biophys 2006
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Liu et al., Oncogene 2010*
• IRef Biogrid Interaction: NEDD8 — TP53 (physical association, affinity chromatography technology) Wang et al., PloS one 2011*
• IRef Hprd Interaction: TP53 — NEDD8 (in vivo) Li et al., Arch Biochem Biophys 2006
• IRef Intact Interaction: Complex of 50 proteins (association, anti tag coimmunoprecipitation) Coffill et al., EMBO Rep 2012
• IRef Intact Interaction: Complex of TP53-FBXO11-NEDD8-UBA3-UBE2M-NAE1 (neddylation reaction, enzymatic study) Abida et al., J Biol Chem 2007

Text-mined interactions from Literome

Liu et al., Oncogene 2010 : In this study we show that NEDD8 ultimate buster 1 (NUB1) , a non-covalent interactor of the Ubl NEDD8 ( neural precursor cell expressed, developmentally downregulated 8 ), controls the localization of p53
Sun et al., J Biol Chem 2010 : Knocking down endogenous NEDD8 suppressed p53 activation induced by knockdown of L30