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BCL2 — GDF15

Text-mined interactions from Literome

Méndez et al., Clin Exp Metastasis 2005 (Breast Neoplasms...) : We found that the genetic damage fraction ( GDF ) increased in 435/Bcl-2 ( GDF=0.55 ) and 435/Bcl-xL cells ( GDF=0.34 ), in regard to 435/Neo control cells ( GDF=0.29 ), indicating that non-random genetic alterations occurred in cells secondary to Bcl-2 or Bcl-xL over-expression
Guo et al., Biochem Cell Biol 2010 (Brain Ischemia) : Our results showed that recombinant human NRG-1 ( 3.0 ng.kg-1 ) significantly increased the expression of p-Akt protein, Bcl-2 mRNA, and the level of p-Bad, respectively, whereas administration of LY294002, a specific inhibitor of PI3K, significantly decreased the expression of p-Akt, p-Bad, and Bcl-2 induced by NRG-1 after a 60 min ischemic insult, followed by 24 h of reperfusion ... These results indicate that NRG-1 may be involved in regulating the expression of Bcl-2 and p-Bad through the PI3K/Akt pathway after transient focal cerebral ischemia