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PTH — RGS2

Text-mined interactions from Literome

Miles et al., Endocrinology 2000 : These findings demonstrate that RGS2 is regulated by PTH , prostaglandin E2, and PTHrP and that regulation by PTH in bone occurs via the cAMP pathway
Ko et al., Biochem Biophys Res Commun 2001 : RGS2 ( Regulator of G protein Signaling 2 ) mRNA was rapidly and transiently increased only by PTH analogs ( PTH1-84, 1-34, 1-31, and PTHrP ) that activated the Galphas mediated cAMP/PKA signaling pathway, whereas activation of the Galphaq mediated Ca ( 2+ ) /PKC signaling pathway by PTH3-34 had no effect on RGS2 expression ... Pretreatment using the Galphas signaling pathway inhibitors SQ22536 and H89 significantly blocked PTH induced RGS2 expression, but the Galphaq signaling pathway inhibitor bisindolylmaleimide I had no effect
Thirunavukkarasu et al., J Cell Biochem 2002 : Functional analysis using RGS-2 overexpression suggests the potential negative regulatory effects of RGS-2 on PTH- and forskolin induced cAMP production in osteoblastic cells ... In summary, our data suggest that PTH treatment results in a direct transcriptional stimulation of RGS-2 that in turn may play a role in modulating the duration/intensity of PTH receptor signaling
Tsingotjidou et al., Bone 2002 : Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate mediated pathway in primary neonatal murine osteoblasts ... To help delineate the molecular mediators of PTH 's opposing effects on skeletal metabolism, we have examined PTH induced regulator of G-protein signaling-2 ( RGS-2 ) expression and function in murine osteoblasts ... We examined the effect of selective signaling agonists and antagonists on RGS-2 expression in MOB cells to determine which pathway ( s ) mediates PTH induced RGS-2 expression ... Overnight treatment with 1 micromol/L PMA to deplete PKC did not affect subsequent RGS-2 induction by PTH , but significantly inhibited PMA induced RGS-2 expression ... Actinomycin D ( 5 microg/mL ) completely blocked 10 nmol/L PTH induced RGS-2 expression ... Finally, we tested the effect of RGS-2 overexpression on PTH- and fluprostenol induced interleukin (IL)-6 promoter activity in MOB cells
Hömme et al., Endocrinology 2003 (Osteosarcoma) : Vitamin D and dexamethasone inversely regulate parathyroid hormone induced regulator of G protein signaling-2 expression in osteoblast-like cells ... PTH induces expression of regulator of G protein signaling (RGS)-2 , a putative preferential inhibitor of G ( q ) -mediated phospholipase C activation ... We investigated whether steroid hormones interfere with PTH signaling by modulating PTH induced RGS-2 expression in osteoblast-like UMR 106-01 cells
Hömme et al., Calcif Tissue Int 2009 : PTH induces RGS-2 , a member of the Regulator of G-protein Signaling protein family, via cAMP/PKA, and inactivates PKC mediated signaling