Hahn et al., J Clin Invest 1978
(Bone Resorption) :
PTH and PTH plus HCT induced increases in bone cyclic AMP ( cAMP ) content were significantly inhibited by DPH but not by phenobarbital
Auszmann et al., Life Sci 1990
:
Phenytoin ( DPH ) reduced PTH stimulated cAMP activity nearly 3-fold in the presence and nearly 1.5-fold in the absence of added calcium
Lerner et al., J Oral Pathol 1985
(Bone Resorption) :
DPH caused a dose dependent, reversible inhibition of PTH and PGE2 stimulated bone resorption at concentrations above 20-30 micrograms/ml without affecting cyclic AMP formation
Somerman et al., Arch Oral Biol 1986
(Bone Resorption) :
Effects of phenytoin ( DPH ) on parathyroid hormone (PTH)- and 1,25-dihydroxyvitamin D3 ( 1,25DHCC ) -mediated bone resorption in bone organ culture were evaluated : it markedly inhibited the actions of both