Tzimas et al., Cell Signal 2006
:
Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation, but did not inhibit Smad mediated transcription activation
Cejas et al., Blood 2010
:
These findings show an unexpected role for the adaptor molecule TRAF6 in Smad mediated TGF-beta signaling and Th17 differentiation