◀ Back to IRS2
IL9 — IRS2
Text-mined interactions from Literome
Demoulin et al., FEBS Lett 2000
:
We show that
IL-9 induces
IRS2 phosphorylation and association with phosphatidylinositol-3 kinase (PI 3-K) p85 subunit in TS1 cells and BaF/9R cells, which proliferate upon IL-9 stimulation
Zhu et al., J Biol Chem 1997
:
However, substitution of the Pro-X-Pro in the BOX1 motif with Ala-X-Ala failed to abolish IL-9 induced cell proliferation but decreased
IL-9 mediated tyrosine phosphorylation of JAK kinases,
insulin receptor substrate-2 , and signal transducer and activator of transcription 3 ( STAT3 ) and expression of c-myc and junB ... Deletion of this region significantly impaired
IL-9 induced cell growth, activation of JAK kinases,
insulin receptor substrate-2 , and STAT3 and expression of early response genes