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AHSA1 — GRAP2
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Sweeney et al., J Biol Chem 2003
:
A chemical inhibitor of
p38 mitogen activated protein kinase ( p38 MAPK ), SB202190, blocked tube formation, and
p38 MAPK activity was
increased in collagen treated cultures, whereas targeting MAPK kinase ( MEK ), focal adhesion kinase ( FAK ), or phosphatidylinositol 3-kinase (PI3K) had little effect
Norgauer et al., Int J Mol Med 2003
:
Moreover, we found that lps induces
p38 stress activated protein kinase ( p38 ) in these cells and inhibitors of
p38 blocked lps induced COX-2 expression and activity
Salvador et al., Nat Immunol 2005
(MAP Kinase Signaling System) :
TCR activation of
p38 lacking Tyr323 was diminished, and blocking of
p38 activity
prevented p38 dual phosphorylation in normal T cells but not in B cells
Wang et al., Am J Respir Cell Mol Biol 2007
:
Moreover, the
p38 MAPK inhibitor, SB203580,
inhibited p38 activity and M-CSF induced monocyte survival
Yang et al., Molecular vision 2007
(Radiation Injuries) :
These results also suggest that
p38 , p44/42, and JNK may regulate glial induced photoreceptor death and that
p38 , JNK, and NF-kappaB may
regulate photoreceptor induced microglial activation
Manzel et al., Am J Respir Cell Mol Biol 2009
:
The expression of C/EBP proteins is not regulated by
p38 mitogen activated protein kinase activation, but
p38 affects gene transcription by increasing the binding of TATA binding protein to TATA-box containing gene sequences
Wu et al., Stem Cells Dev 2010
:
Robust
p38 MAPK activity between embryoid body culture days 3 and 4 is crucial for cardiomyogenesis of ES cells, and specific inhibition of
p38 MAPK activity at this time
results in ES cell differentiation into neurons rather than cardiomyocytes
Ito et al., Mol Hum Reprod 2010
(MAP Kinase Signaling System) :
Although the
p38 activators, FSH and tumor necrosis factor-a,
induced a similar localization of phosphorylated
p38 in KGN cells, the expression and localization patterns of p38 were distinct from those in older granulosa cells and H ( 2 ) O ( 2 ) -treated KGN cells
Li et al., J Trauma 2011
(Disease Models, Animal...) :
TH increases phosphorylation of
p38? during both HS and early resuscitation, but
attenuates phosphorylation of
p38a , increases Akt/HspB1 interaction, and modulates Akt phosphorylation during HS and resuscitation
Aires et al., Biochim Biophys Acta 2012
:
In the brain, IF
induced the expression of inflammatory genes and
p38 MAPK phosphorylation, while the addition of PAO reduced brain inflammatory gene expression and
p38 MAPK phosphorylation
Cheng et al., Invest Ophthalmol Vis Sci 2013
(Burns, Chemical...) :
Artesunate activated
p38MAPK , and specific
p38MAPK inhibitors
suppressed artesunate induced apoptosis in endothelial cells