Shan et al., Prostaglandins Leukot Essent Fatty Acids 2012
(Anoxia) :
Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126, a MEK inhibitor, as well as by NDGA and CDC , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190
Gregus et al., FASEB J 2013
(Hyperalgesia) :
CDC potently inhibited HXS and 12-LOX activity in vitro ( relative IC50s : CDC, ~0.5 and 0.8 µM, respectively ) and carrageenan evoked tactile allodynia in vivo