Okano et al., J Cardiovasc Pharmacol 2006
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Tyrosine phosphorylation of eNOS and expression of calmodulin increased, but Hsp90 decreased with all treatments and only raloxifene treatment increased caveolin-1 compared with OVX
Michel et al., J Biol Chem 1997
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We now report that in endothelial cells the interaction between eNOS and caveolin is importantly regulated by Ca2+-calmodulin Feron et al., Biochemistry 1998
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We conclude that the regulatory eNOS-caveolin association is independent of the state of eNOS acylation, indicating that agonist evoked Ca2+/CaM dependent disruption of the caveolin-eNOS complex, rather than agonist promoted depalmitoylation of eNOS, relieves caveolin 's tonic inhibition of enzyme activity