◀ Back to NOS3
CSRP1 — NOS3
Text-mined interactions from Literome
Sjöholm et al., Lancet 2005
(Arteriosclerosis...) :
Subodh Verma and associates ( Circulation 2004 ; 109 : 2058-67 ) recently showed that CRP attenuates the survival, differentiation, and function of endothelial progenitor cells, partly by
CRP reducing expression of endothelial
nitric-oxide synthase
Mineo et al., Circ Res 2005
:
Thus FcgammaRIIB mediates
CRP inhibition of
eNOS via PP2A, providing a mechanistic link between CRP and endothelial dysfunction
Xu et al., Mol Endocrinol 2007
(Insulin Resistance...) :
Recombinant
CRP suppressed insulin induced NO production,
inhibited the phosphorylation of Akt and endothelial
nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner
Tanigaki et al., Circ Res 2009
:
We previously showed that
CRP inhibits
eNOS activation by insulin by blunting Ser1179 phosphorylation ... Thus,
CRP inhibits
eNOS stimulation by insulin via FcgammaRIIB and its ITIM, SHIP-1 activation, and resulting blunted activation of Akt
Tanigaki et al., Diabetes 2013
(Insulin Resistance) :
CRP does not
impair skeletal muscle glucose delivery in Fc?RIIB ( -/- ) mice or in endothelial
nitric oxide synthase knock-in mice with phosphomimetic modification of Ser1176, which is normally phosphorylated by insulin signaling to stimulate nitric oxide mediated skeletal muscle blood flow and glucose delivery and is dephosphorylated by CRP/Fc?RIIB