Frisancho-Kiss et al., J Immunol 2007
(Coxsackievirus Infections...) :
We show that TLR4 and IFN-gamma levels are significantly elevated and regulatory T cell ( Treg ) populations significantly reduced in the heart of males following CVB3 infection, whereas females have significantly increased T cell Ig mucin (Tim)-3 , IL-4 and Treg
Anderson et al., Expert Opin Ther Targets 2007
(Autoimmune Diseases) :
Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man