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IFNG — MAP3K4
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of ANXA2-MAP3K4
→
IFNG
(increases)
Halfter et al., Biochem J 2005*
Evidence: Furthermore, the calcium-binding protein, annexin II, and the calcium-regulated kinase, Pyk2, co-immunoprecipitate with MEKK4 after treatment with IFNgamma.
-
OpenBEL Selventa BEL large corpus:
Complex of MAP3K4-PTK2B
→
IFNG
(increases)
Halfter et al., Biochem J 2005*
Evidence: Furthermore, the calcium-binding protein, annexin II, and the calcium-regulated kinase, Pyk2, co-immunoprecipitate with MEKK4 after treatment with IFNgamma.
Text-mined interactions from Literome
Chi et al., EMBO J 2004
(MAP Kinase Signaling System) :
Thus,
MEKK4 mediates the action of GADD45beta and GADD45gamma on p38 activation and
IFNgamma production
Halfter et al., Biochem J 2005
(Calcium Signaling) :
Interferon-gamma dependent tyrosine phosphorylation of
MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes