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IGF2 — PTPN11
Text-mined interactions from Literome
MaƱes et al., Mol Cell Biol 1999
(Neoplasm Invasiveness) :
On the other hand,
IGF-I promotes the association of insulin receptor substrate 1 with the focal adhesion kinase ( FAK ), paxillin, and the tyrosine phosphatase
SHP-2 , resulting in FAK and paxillin dephosphorylation
Kwon et al., Endocrinology 2006
:
Similarly in cells expressing native SHP-2,
IGF-I induced
SHP-2 binding to p85, whereas in cells expressing SHP-2/C459S, there was no increase
Shen et al., Cell Mol Life Sci 2010
(MAP Kinase Signaling System) :
In vascular smooth muscle cells,
IGF-I stimulates
SHPS-1/SHP2/Src complex formation which is required for IGF-I stimulated cell proliferation