◀ Back to TNF
SCG2 — TNF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ait-Ali et al., Mol Endocrinol 2004
:
TNF-alpha and IL-1 induced a time- and dose dependent
increase in galanin, vasoactive intestinal polypeptide, and
secretogranin II mRNA levels
Harada et al., J Interferon Cytokine Res 2004
:
The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced IFN-gamma,
TNF-alpha and IL-12p70 in the
presence of
SCG
Harada et al., J Interferon Cytokine Res 2006
:
We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently
induced by
SCG to produce interferon- gamma (IFN-gamma),
tumor necrosis factor-alpha (TNF-alpha) , granulocyte-macrophage colony stimulating factor ( GM-CSF ), and interleukin-12p70 (IL-12p70), and that GM-CSF plays a key biologic role among these cytokines ... Cell-cell contact involving intercellular adhesion molecule-1 ( ICAM-1 ) and lymphocyte function associated antigen-1 ( LFA-1 ) was an essential step for the induction of GM-CSF and IFN-gamma by SCG but not for the
induction of
TNF-alpha or IL-12p70 by
SCG ...
SCG directly
induced adherent splenocytes to produce
TNF-alpha and IL-12p70 ... GM-CSF was required for the
induction of
TNF-alpha by
SCG , and in turn, TNF-alpha enhanced the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG
Harada et al., Microbiol Immunol 2006
(Leukopenia) :
The levels of interferon-(IFN-)gamma,
tumor necrosis factor-(TNF-)alpha , granulocyte-macrophage-colony stimulating factor ( GM-CSF ), interleukin-(IL-) 6 and IL-12p70 were significantly
increased by
SCG in CY-treated mice ... Neutralizing GM-CSF significantly inhibited the
induction of IFN-gamma,
TNF-alpha and IL-12p70 by
SCG ... Blocking dectin-1 significantly inhibited the
induction of
TNF-alpha and IL-12p70 production by
SCG
Harada et al., J Interferon Cytokine Res 2008
:
Blocking dectin-1 significantly inhibited the
induction of
TNF-alpha production by
SCG
Hida et al., Inflamm Res 2009
:
The
effect of
SCG on
TNF-alpha production was partially inhibited by CRDO
Bissonnette et al., Int Arch Allergy Immunol 1995
:
However,
SCG , NED, and IFN inhibit TNF-alpha dependent cytotoxicity by both PMCs and IMMCs and
reduce the steady-state levels of mRNA for
TNF-alpha in PMCs ... The inhibitory
effect of
SCG and NED on
TNF-alpha release from MCs may explain some of their anti-inflammatory and therapeutic effects