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SERPINE1 — TNF
Text-mined interactions from Literome
Cigolini et al., Atherosclerosis 1999
(Obesity) :
Furthermore our data support the possibility of a main
role of endogenous
TNF-alpha on human adipose tissue
PAI-1 expression
Sakamoto et al., Am J Physiol 1999
:
To identify mechanism ( s ) through which
TNF-alpha induces
PAI-1 , 3T3-L1 preadipocytes were differentiated into adipocytes and exposed to TNF-alpha for 24 h. TNF-alpha selectively increased the synthesis of PAI-1 without increasing activity of plasminogen activators ... Both superoxide ( generated by xanthine oxidase plus hypoxanthine ) and hydrogen peroxide were potent inducers of PAI-1, and hydroxyl radical scavengers completely abolished the
TNF-alpha induction of
PAI-1 ... Because
induction of
PAI-1 by
TNF-alpha is potentiated synergistically by insulin, both agonists appear likely to contribute to the impairment of fibrinolytic system capacity typical in obese, hyperinsulinemic patients
Swiatkowska et al., Eur J Biochem 2000
(MAP Kinase Signaling System) :
In contrast to exogenously released NO that significantly reduced mostly basal PAI-1 expression, endogenously generated NO by NOS potentiated
TNFalpha induced upregulation of
PAI-1 expression
Birgel et al., Arterioscler Thromb Vasc Biol 2000
:
Moreover,
TNF-alpha and interkeukin-1beta ( IL-1beta ) also exerted a stimulatory effect on PAI-1 release and
increased PAI-1 mRNA levels ... In addition, data suggest that
TNF-alpha and IL-1beta also have stimulatory effects on PAI-1 protein secretion and may
contribute to the elevated
PAI-1 levels observed in obesity
Midorikawa et al., Biochem Biophys Res Commun 2000
(Arteriosclerosis...) :
Secretion of TGFbeta ( transforming growth factor beta ) and
TNFalpha ( tumor necrosis factor alpha ), possible
regulators of
PAI-1 expression and secretion, were not stimulated by treatment with 1.0 mM homocysteine
Lopez et al., Atherosclerosis 2000
:
In TNFalpha stimulated cells, ATOR and FLU had a modest down modulating effect ( -17 and -20 %, respectively ) on
TNFalpha induced increase in
PAI-1 synthesis
Soeda et al., Biochim Biophys Acta 2001
:
The stimulating
effect of
TNF-alpha on
PAI-1 synthesis was attenuated by the pretreatment of HUVEC with daunorubicin ... Fumonisin B ( 1 ) treatment restored the daunorubicin induced decrease in PAI-1 release to approximately 70 % of the control, but did not affect the
TNF-alpha induced increase in
PAI-1 release
Peiretti et al., J Biol Chem 2001
:
A reduced p70 S6 kinase ( p70 ( S6K ) ) phosphorylation was also observed and, in this situation,
TNF dramatically
enhanced PAI-1 synthesis ... Similarly,
TNF significantly
up-regulated PAI-1 synthesis when p70 ( S6K ) phosphorylation was inhibited by rapamycin
Chen et al., Thromb Haemost 2001
(MAP Kinase Signaling System) :
PAI-1 gene
activation by
TNF-alpha apparently is yet to be defined for the location of the response element and/or the signaling pathway, while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5 ' proximal promoter
Montes et al., Thromb Haemost 2002
(Disseminated Intravascular Coagulation...) :
Previous findings suggest that
tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are
responsible for the increase in the level of
PAI-1 ... These results suggest that
PAI-1 increase might be
independent of
TNF-alpha and IL-1beta
Gruber et al., Blood 2003
(Arteriosclerosis) :
Using reporter gene analysis, we could identify a region in the PAI-1 promoter that contributes to basal expression as well as to
tumor necrosis factor alpha (TNFalpha) induction of
PAI-1 in endothelial cells
Swiatkowska et al., Cell Mol Biol Lett 2002
:
Because TNFalpha induces PAI-1 production in endothelial cells, and NAC attenuated this response, we attempted to investigate the possible involvement of ROS in the
activation of
PAI-1 by
TNFalpha ...
Upregulation of
PAI-1 expression in endothelial cells by the stimulation with
TNFalpha ( 50 ng/ml ) or H2O2 ( 10-200 micro M ), observed by measurement of the antigen and mRNA levels, was reversed in the presence of NAC ( 20mM )
Pawłowska et al., Cell Mol Biol Lett 2002
:
We observed an inhibition of stimulatory
effect of
TNFalpha on
PAI-1 expression also at the level of the PAI-1 promoter in cells transfected with a PAI-1 promoter fragment ( +71 to -800 )
Pandey et al., Am J Pathol 2003
:
However, in lean mice,
TNF-alpha induced
PAI-1 expression is mediated primarily by the p55 TNFR ... These observations suggest that the p75 TNFR may play a role in attenuating
TNF-alpha induced
PAI-1 mRNA expression in acute inflammatory conditions
Peiretti et al., J Cell Physiol 2003
:
This lack of effect was not due to a default of TNFalpha signaling since
PAI-1 synthesis was still stimulated in
response to exogenous
TNFalpha
Nordt et al., Thromb Haemost 2003
(Arteriosclerosis) :
PAI-1 gene and protein expression were
induced consistently by TGF-beta ( up to 4.0-fold ), PDGF ( 2.1-fold ),
TNF-alpha ( 1.7-fold ), and thrombin ( 2.3-fold )
Li et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2002
:
The MAPKK inhibitor ( PD98059, 60 mumol/L ) could markedly inhibit
PAI-1 activity and mRNA expression
induced by
TNF-alpha ( 100 U/ml ) or mmLDL ( 50 micrograms/ml ) ... ( 1 )
TNF-alpha or mmLDL could
induce PAI-1 activity and mRNA expression in HUVECs ... ( 2 ) Increase of
PAI-1 activity
induced by
TNF-alpha and mmLDL was related to its mRNA expression ... ( 3 ) The MAPK pathway may play a role in
PAI-1 expression
induced by
TNF-alpha or mmLDL
Arndt et al., Biochim Biophys Acta 1992
(Carcinoma, Hepatocellular...) :
The presence of both interleukin-6 (IL-6) and
tumor necrosis factor alpha (TNF) also
increased UK and
PAI-1 levels, although not as dramatically as IL-1
Idell et al., Am J Respir Cell Mol Biol 1992
(Inflammation...) :
HPMC
PAI-1 is
increased by transforming growth factor-beta ( TGF-beta ) and
tumor necrosis factor-alpha (TNF-alpha) , as is tPA release, while PAI-1 mRNA is unchanged and tPA mRNA is increased
Kassis et al., Blood 1992
:
Enzyme linked immunosorbent assay and immunoneutralization experiments indicate that
tumor necrosis factor-alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) do not
contribute to the postoperative plasma effect on HUVEC
PAI-1 synthesis
Idell et al., Am J Physiol 1992
:
In dose and time-course studies, HLF plasminogen activator inhibitor-1 ( PAI-1 ) was increased by TGF-beta, whereas
TNF-alpha induced release of
PAI-1 into the media
Hamaguchi et al., J Pharmacol Exp Ther 2003
:
TNF-alpha induced
PAI-1 mRNA expression and protein production in human umbilical vein endothelial cells ( HUVECs ) ... A specific inhibitor for p38 mitogen activated protein kinase, 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ( SB 203580 ), and a protein kinase C inhibitor, calphostin C, had no inhibitory effects on
TNF-alpha induced
PAI-1 secretion ... A protein tyrosine kinase inhibitor, genistein, completely inhibited TNF-alpha induced PAI-1 secretion, whereas an inhibitor of extracellular signal regulated kinase ( ERK ) kinase, 2'-amino-3'-methoxyflavone ( PD98059 ), and a nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, partly inhibited
TNF-alpha induced
PAI-1 secretion ... Together, PD98059 and emodin completely inhibited
TNF-alpha induced
PAI-1 secretion, suggesting that both NF-kappaB dependent and NF-kappaB independent pathways are involved in TNF-alpha induced signal pathway to PAI-1 production and that the latter pathway is mediated by activation of ERK ... Furthermore, we have shown that troglitazone inhibited both
TNF-alpha induced
PAI-1 protein secretion and mRNA in HUVECs ... Genistein, but neither PD98059 nor emodin, was additive to the inhibitory effect of troglitazone on
TNF-alpha induced
PAI-1 secretion
Muth et al., Crit Care Med 2004
:
In all EC, stimulation with
tumor necrosis factor-alpha and lipopolysaccharide
increased the expression of
PAI-1 , PAI-2, and u-PA and decreased t-PA expression
Bauer et al., J Clin Endocrinol Metab 2004
:
Induction of
PAI-1 by
TNF alpha could be related to restricted trophoblast invasion in preeclampsia
Hou et al., J Biol Chem 2004
:
Although
TNFalpha is a potent
inducer of
PAI-1 expression in vitro and in vivo, the precise location of the TNFalpha response site in the PAI-1 promoter has yet to be determined
Torii et al., Rinsho Byori 2005
(Glomerulonephritis...) :
We also closely examined the
effects of hypoxia and
TNF-alpha on
PAI-1 expression in cultured human proximal renal tubular cells ( HRCs )
Sopasakis et al., Int J Obes Relat Metab Disord 2005
:
TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and
PAI-1 , but not leptin
Liu et al., Biochem Biophys Res Commun 2005
:
Thiazolidinediones inhibit
TNFalpha induction of
PAI-1 independent of PPARgamma activation ... In an endothelial cell line, Rosiglitazone ( RG ) and Pioglitazone ( PG ) inhibited
induction of
PAI-1 by
TNFalpha ... The observations suggest TZDs inhibit
TNFalpha mediated
PAI-1 induction independent of inducible PPARgamma activation and this may involve in the modulation of Nur77/Nurr1 expression and NP binding to the PAI-1 NBRE
Li et al., Kidney Int 2005
(Anoxia) :
Synergistic
effect of hypoxia and
TNF-alpha on production of
PAI-1 in human proximal renal tubular cells ... We also closely examined the
effects of hypoxia and
tumor necrosis factor-alpha (TNF-alpha) on
PAI-1 expression in cultured human proximal renal tubular cells ( HPTECs ) ...
TNF-alpha can synergistically
enhance this hypoxia induced
PAI-1 expression
Zhou et al., J Cell Biochem 2005
:
We found that SalB inhibited
TNF-alpha induced
PAI-1 mRNA production and protein secretion in HUVECs ... Treatment with SalB ( 0.05 and 0.15 microM ) notably attenuated
TNF-alpha induced expression of
PAI-1 to 90.5 % and 74.6 %, respectively, after 12 h, and to 75.1 % and 64.2 %, respectively, after 18 h ... We found that the c-Jun N-terminal kinase (JNK) inhibitor, SP600125, increased the inhibitory effects of SalB on
TNF-alpha induced
PAI-1 secretion, whereas the nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, and the extracellular signal regulated kinase ( ERK ) inhibitor, PD98059, did not ... Collectively, these results indicate that the NF-kappaB and ERK-AP-1 pathways are possible targets of SalB in the regulation of
TNF-alpha stimulated
PAI-1 production in HUVECs
Kimura et al., Rinsho Byori 2005
(Anoxia...) :
In the present study, we examined the
effects of hypoxia and
TNF-alpha on
PAI-1 , MCP-1 and VEGF expression in cultured human proximal renal tubular cells ( HPTECs ) ... Hypoxia,
TNF-alpha and their combination
induced a 2.8-fold, a 1.8-fold, and a 4.6-fold increase in
PAI-1 protein secretion, and produced a 3.6-fold, a 3.3-fold, and a 12.1-fold increase at the PAI-1 mRNA level, respectively
Swiatkowska et al., FEBS J 2005
:
We have shown that
TNFalpha induced expression and gene transcription of
PAI-1 involves a regulatory region present in segment -664/-680 of the PAI-1 promoter ... We show that
activation of
PAI-1 gene by
TNFalpha and reactive oxygen species is mediated by interaction of NF-kappaB with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter
Huber et al., Placenta 2006
:
TNFalpha mediated induction of
PAI-1 restricts invasion of HTR-8/SVneo trophoblast cells
Zhang et al., Vascul Pharmacol 2006
:
Notoginsenoside R1 from Panax notoginseng inhibits
TNF-alpha induced
PAI-1 production in human aortic smooth muscle cells ... These results suggest that notoginsenoside R1 inhibits
TNF-alpha induced
PAI-1 overexpression in HASMCs by suppressing ERK and PKB signaling pathways
Slivka et al., Biochim Biophys Acta 1991
:
Moreover, when PK-C was down-regulated by PMA pretreatment, subsequent
induction of
PAI-1 by transforming growth factor beta ( TGF beta ) and
tumor necrosis factor alpha (TNF alpha) was unaltered, and induction by lipopolysaccharide (LPS) was decreased by only 50 % ... Agents which increase cAMP, ( e.g., forskolin and isobutylmethylxanthine ) blocked the
induction of
PAI-1 synthesis by PMA, LPS, TGF beta and
TNF alpha suggesting that induction may occur by lowering cAMP
Takeshita et al., Metabolism 2006
(Diabetes Mellitus, Type 2...) :
To address the mechanism underlying the up-regulation of hepatic PAI-1 in obesity, we tested the
effects of
tumor necrosis factor alpha (TNF-alpha) , an important link between obesity and insulin resistance, on
PAI-1 production in the nonmalignant human hepatocyte cell line, THLE-5b ... A thiazolidinedione, pioglitazone, reduced
TNF-alpha induced
PAI-1 production by 32 %, via protein kinase C- and nuclear factor-kappaB dependent pathways ... The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor cerivastatin inhibited
TNF-alpha induced
PAI-1 production by 59 %, which was reversed by coincubation with mevalonic acid
Mukai et al., Am J Physiol Heart Circ Physiol 2007
:
The
induction of
PAI-1 by
TNF-alpha and insulin is mediated, in part, by ERK and p38 MAPK
Takeshita et al., Eur J Pharmacol 2008
(Diabetes Mellitus, Type 2...) :
We next examined the role of the renin-angiotensin system on
TNF-alpha induced
PAI-1 production in the nonmalignant human hepatocyte cell line THLE-5b ... Moreover, angiotensin AT(1) receptor antagonist dose-dependently inhibited
TNF-alpha induced
PAI-1 production
Liu et al., J Endocrinol 2008
:
Taken together, these observations suggest that GLP-1 inhibits
TNF-alpha mediated
PAI-1 induction in vascular endothelial cells, and this effect may involve Akt mediated signalling events and the modulation of Nur77 expression and NP binding to the PAI-1 NBRE
Kimura et al., Nephrol Dial Transplant 2008
(Inflammation) :
It also enhanced hypoxia-, TNF-alpha- and hypoxia plus
TNF-alpha stimulated
PAI-1 expression at the mRNA and protein levels
Deng et al., J Pharmacol Exp Ther 2008
:
The prolonged
TNF-alpha production
enhanced PAI-1 production after RAN cotreatment, and this is important for the hepatotoxicity
Ding et al., Cell Biol Int 2008
(Carcinoma, Hepatocellular...) :
Ghrelin, a recently described orexigenic peptide hormone, attenuates
PAI-1 induced by
TNF-alpha in the human hepatoma cell line ( HepG2 ) ... Exposure to TNF-alpha ( 1 ng/ml ) for 24h caused a significant increase in PAI-1 mRNA expression and protein secretion, as evaluated by RT-PCR and ELISA, but pretreatment with ghrelin ( 1-100 ng/ml ) inhibited both basal and
TNF-alpha induced
PAI-1 release in a dose and time dependent manner in HepG2 ... The results indicate that ghrelin inhibits both basal and
TNF-alpha induced
PAI-1 production via NF-kappaB pathway in HepG2 cells, and suggest that the peptide plays a therapeutic role in atherosclerosis, especially in obese patients with insulin resistance, in whom ghrelin levels were reduced
Niiya et al., Rinsho Ketsueki 1991
(Leukemia, Promyelocytic, Acute) :
As with the case of PMA,
TNF-alpha and IL-6 induced PL-21 cells to macrophage-like cells, but did not
affect the
PAI activity
Kimura et al., Nephrol Dial Transplant 2009
(Fibrosis) :
Dexamethasone enhances basal and
TNF-alpha stimulated production of
PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells ... DXA further increased
TNF-alpha stimulated
PAI-1 expression via the GR
Sawdey et al., J Clin Invest 1991
:
However, the greatest responses to TGF-beta were observed in adipose tissue and the kidney, while LPS and
TNF-alpha strongly
stimulated PAI-1 gene expression in the liver, kidney, lung, and adrenals ... These results demonstrate that the PAI-1 gene is regulated in a complex and tissue-specific manner in vivo, and suggest a
role for
TNF-alpha in the response of the
PAI-1 gene to sepsis
Jerczynska et al., Regul Pept 2009
:
Its analogue, 8-Br-cGMP alone had no effect but significantly inhibited
TNFalpha induced expression of
PAI-1 ... Similarly, CNP and the inhibitors of ERK1/2 ( PD098059 ) and PI3K ( LY294002 ) attenuated
PAI-1 expression
induced by
TNFalpha
Bergh et al., Biochem Biophys Res Commun 2009
(Thrombosis) :
Shear stress and
TNF-alpha additively
induced PAI-1 , whereas shear stress blocked the cytokine effect on t-PA and u-PA
Riedo et al., J Immunol 1990
:
Neither the LPS- or
TNF induced expression of
PAI-1 nor the dLPS inhibition of the LPS response was mediated by prostanoids
Cao et al., Acta Diabetol 2013
:
Furthermore,
PAI-1 was also upregulated in the
presence of
TNF-a and glucose ...
TNF-a induced Egr-1 protein expression and
PAI-1 levels through the ERK1/2 pathway
Zou et al., Toxicology 2011
(Drug-Induced Liver Injury) :
TNF had no effect on
PAI-1 production or fibrin deposition
Wu et al., Circ J 2012
:
In cultured human endothelial cells, GlcN time- and concentration-dependently increased
PAI-1 protein level that was further
enhanced by
tumor necrosis factor (TNF)-a , which was accompanied by a transient synergistic activation of p38mapk ... The
stimulation of
PAI-1 by GlcN alone or by GlcN and
TNF-a in combination was inhibited by the specific inhibitor of p38mapk, but not that of JNK or ERK1/2
Lobo et al., Cytokine 2012
:
Simvastatin also attenuated the increase in expression and secretion of
PAI-1 induced by
TNF-a ( 16898.6 ± 1663.3 vs 12922.1 ± 843.9 and 5.19 ± 3.12 vs 0.59 ± 0.16, respectively p < 0.05 ), but under baseline conditions had no effect on the expression or secretion of PAI-1 ... Our findings suggested that simvastatin counteracted the stimulatory
effect of
TNF-a on secretion and expression of MCP-1,
PAI-1 and adiponectin, implying a potential anti-atherogenic effect during the inflammatory process ; these pleitropic effects were more pronounced with HMG-CoA reductase inhibitor
van den Berg et al., Thromb Haemost 1988
:
Cultured human endothelial cells increase their
PAI-1 production upon
stimulation with LPS and
TNF , agents that are known to cause an increase in PAI-1 levels in vivo
van Hinsbergh et al., Blood 1988
:
The monokine
tumor necrosis factor ( human recombinant TNF )
increased the production of
PAI by cultured human endothelial cells from umbilical vein ( twofold ) and from foreskin microvessles ( four to eight fold ) ... The
stimulation of
PAI activity by
TNF was seen at 4 U/mL and reached a maximum at 500 U/mL ... Therefore, it is most likely that vascular endothelial cells contribute to the increased amount of circulating
PAI induced by
TNF in vivo
Dosne et al., Thromb Res 1988
:
TNF ( 1-1000 pg/ml )
induced a dose dependent increase in
PAI level in the supernatant from 6 to 25 U/ml as estimated against urokinase
Ferran et al., Biochem Biophys Res Commun 1995
:
We show that pyrrolidine dithiocarbamate strongly reduces the
TNF alpha mediated
induction of E-selectin, VCAM-1, ICAM-1,
PAI-1 , tissue factor, IL-8 and I kappa B-alpha
Panagakos et al., Inflammation 1995
(Osteosarcoma) :
Although
TNF-alpha suppresses the induced increase in steady-state mRNA levels of u-PA and
PAI-1 during maturation of extracellular matrix ( ECM ), the u-PA/PAI-1 ratio is altered in such a way that PA activity associated with the ECM is higher than control cells
Emeis et al., Blood 1995
:
Thus, the data suggest that, in rats in vivo,
TNF-alpha and IL-1 are not significantly
involved in the induction of
PAI-1 by endotoxin
van Hinsbergh et al., Blood 1994
:
In contrast to
TNF-alpha induced
PAI-1 production, the transcription and synthesis of urokinase-type plasminogen activator ( u-PA ) was not inhibited by genistein ... A TNF-alpha-mutant ( Trp32Thr86TNF alpha ) that specifically recognizes the 55-kD TNF-receptor, mimicked the
effects of
TNF alpha on both
PAI-1 and u-PA
Campbell et al., Biochim Biophys Acta 1994
(Joint Diseases) :
The
effects of
TNF alpha and TGF-beta on
PAI-1 antigen levels were both time- and concentration dependent ; optimum doses being 10-100 pM TNF alpha and 0.4-0.8 nM TGF-beta, with each cytokine exerting its effect on PAI-1 antigen levels within 8 h of addition to culture
Whawell et al., Br J Surg 1994
:
Thus
TNF may
mediate increased
PAI-1 release in inflamed peritoneum ...
TNF significantly
increased the mean ( s.e.m. ) release of
PAI-1 by human peritoneal mesothelial cells in vitro at 4 h ( control 1.84 ( 0.17 ) ng/micrograms versus TNF 2.37 ( 0.17 ) ng/micrograms, P < 0.05 ), 6 h ( 2.53 ( 0.09 ) versus 3.88 ( 0.46 ) ng/micrograms, P < 0.05 ), 18 h ( 0.50 ( 0.02 ) versus 1.04 ( 0.11 ) ng/micrograms, P < 0.05 ) and 24 h ( 0.87 ( 0.05 ) versus 1.35 ( 0.11 ) ng/micrograms, P < 0.05 )
Yamamoto et al., Biol Pharm Bull 1993
:
In contrast,
PAI-1 : Ag release was significantly
increased by either IL-1 beta or
TNF alpha ; ET-1 significantly reduced the stimulatory effect of the cytokines
Zoellner et al., Thromb Haemost 1993
:
IL-1 alpha and
TNF alpha increased the synthesis of PAI-2 and
PAI-1 by EC in a dose dependent manner
Samad et al., J Clin Invest 1996
:
Endotoxin also
induced PAI-1 in endothelial cells, while
TNF-alpha additionally induced it in smooth muscle cells
Lee et al., Circ Res 1996
:
Enzyme linked immunosorbent assay of culture media showed that
TNF-alpha ( 10 ng/mL )
increased PAI-1 secretion by 4.2 fold compared with control ( 105.5 +/- 9.6 ) versus 24.9 +/- 1.7 ng/mL, n = 3 ) ... In addition, the
induction of
PAI-1 by
TNF-alpha and plasminogen suggests a negative feedback mechanisms limit both plasmin mediated and MMP mediated matrix degradation
Sitrin et al., J Leukoc Biol 1996
(Leukemia, Myeloid) :
Anti-uPA monoclonal antibody ( mAb ) suppressed LPS-driven
TNF-alpha secretion by 61.6 +/- 5.9 % ( P < .001 ), and
PAI-1 , a uPA inhibitor,
suppressed it to 53.1 +/- 8.2 % of the control value ( P < .001 )
Kornelisse et al., J Infect Dis 1996
(Meningococcal Infections...) :
Thus, an increased
PAI-1 response to
TNF-alpha may be associated with fatality, probably because of polymorphism of the PAI-1 gene
Le Magueresse-Battistoni et al., Endocrinology 1997
:
TNF alpha action on
PAI-1 , like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate ( a stimulator of protein kinase C ) and strongly reduced by staurosporine ( an inhibitor of the protein kinase C ) ... Together, the present findings suggest that some of the biological
effects of
TNF alpha on
PAI-1 might be secondary to de novo synthesis of EGFR ... Because TNF alpha probably originates from testicular macrophages, such a
regulation of
PAI-1 by
TNF alpha may occur in the context of physiological interactions between the testis and the immune system
Samad et al., Ann N Y Acad Sci 1997
(Aneurysm...) :
Since both TNF-alpha and insulin are known to increase in obesity, the elevated levels of
PAI-1 observed in the plasma of obese individuals may
result from
TNF-alpha and/or insulin induction of PAI-1 in the adipose tissue itself
Yamashita et al., Thromb Res 1997
:
Although a recent study insists that inhibition of
tumor necrosis factor alpha (TNF alpha) does not
reduce the induction of
PAI-1 by endotoxin in rats, we imagine that TNF alpha is involved in the induction of PAI-1 by endotoxin, because endotoxin treatment induces TNF alpha and administration of TNF alpha induces PAI-1 both in vitro and in vivo ... These results suggest that
TNF alpha is
responsible , at least in part, for the induction of
PAI-1 by endotoxin in vivo
Estellés et al., Thromb Haemost 1998
(Pre-Eclampsia...) :
The elevated
TNFalpha in the placenta may
induce PAI-1 and TF, and thus promote the thrombotic alterations associated with preeclampsia
Soeda et al., Biochim Biophys Acta 1998
:
The increase in PAI-1 release by this mechanism was suppressed by a cyclooxygenase inhibitor, aspirin, whereas the inhibitor did not affect
TNF-alpha induced increase in
PAI-1 release