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IL8 — TGFB1
Text-mined interactions from Literome
Fujisawa et al., Placenta 2000
(Choriocarcinoma...) :
In contrast to IL-6, the expression of
IL-8 was not
affected by
TGF-beta1
Fong et al., Am J Physiol Lung Cell Mol Physiol 2000
:
TGF-beta1 stimulates
IL-8 release, COX-2 expression, and PGE ( 2 ) release in human airway smooth muscle cells ... In this study, we tested the ability of
transforming growth factor (TGF)-beta1 to
stimulate IL-8 release, cyclooxygenase (COX)-2 expression and PGE ( 2 ) generation in cultured human ASM cells and explored the role of COX products and COX-2 induction on IL-8 release ... These results show for the first time that
TGF-beta1 stimulates IL-8 release, COX-2 induction, and PGE ( 2 ) generation in human ASM cells and that PGE ( 2 ) generation is not
critical for TGF-beta1 induced
IL-8 release
Wang et al., Inflamm Res 2001
:
The differential
effects of
TGF-beta1 on
IL-8 secretion from suspended and adherent cells could not be explained by differences in IL-1 receptor antagonist production
Kelley et al., Am J Respir Cell Mol Biol 2001
(Cystic Fibrosis...) :
Our data demonstrate that both CF-phenotype cells lacking Smad3 expression, and A549 cells expressing a dominant negative Smad3, are unable to support
TGF-beta1 mediated inhibition of either the
interleukin (IL)-8 or the NOS2 promoter
Bry et al., Am J Obstet Gynecol 1992
(Obstetric Labor, Premature) :
Human amnion cells in monolayer culture were treated with
interleukin-1 , tumor necrosis factor, or vehicle in the
presence or absence of
transforming growth factor-beta
Wondergem et al., Atherosclerosis 2004
:
Compared to cultures exposed to injury alone, radiation
induced significant ( P < 0.05 ) increases in mRNA levels of
IL-8 ( 1.35 +/- 0.10-fold increase at 4h ), FGF-2 ( 1.62 +/- 0.10-fold at 4h ; 1.76 +/- 0.33-fold at 24h ) and IL-1beta ( 2.76 +/- 0.40-fold at 24h ), whereas mRNA levels of
TGF-beta1 , PDGF-A and PDGF-B increased about 1.2-fold
Méndez-Dávila et al., J Endocrinol Invest 2004
(Osteoporosis) :
We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and
interleukin-1 stimulated interleukin (IL)-6,
transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Liu et al., Cytokine 2005
(Melanoma) :
Selective
induction of
interleukin-8 expression in metastatic melanoma cells by
transforming growth factor-beta 1 ... We investigated the
effects of
TGF-beta1 on
IL-8 expression in the well characterized A375 human melanoma system ... We demonstrated by enzyme linked immunoassay and Northern blot analysis that
TGF-beta1 selectively
induced IL-8 expression, at both protein and mRNA levels, in highly metastatic A375SM cells but not cells of their poorly metastatic parental line A375P ... Transient transfection with luciferase reporter gene constructs revealed that
TGF-beta1 activated
IL-8 promoter activity in A375SM cells but not A375P cells ... Studies with progressive 5 ' deletion constructs and site-specific mutations demonstrated that a construct containing -133 to +44 of the 5'-flanking sequence was necessary and sufficient for maximal TGF-beta1 induced transcription response and that
TGF-beta1 induced activation of
IL-8 promoter depended on AP-1 ( -126 to -120 bp ), NF-kappaB ( -94 to -71 bp ), and C/EBP-like factor NF-IL6 ( -94 to -81 bp ) in this region ... Our data thus demonstrated that
TGF-beta1 selectively
induced IL-8 expression in highly metastatic A375SM melanoma cells ... This
TGF-beta1 induced
IL-8 expression could be an amplification cascade responsible for overexpression of IL-8 in human melanoma and one of potential mechanisms by which TGF-beta1 promotes angiogenesis, growth, and metastasis of human melanoma
Qi et al., American journal of physiology. Renal physiology 2006
:
TGF-beta1 induces
IL-8 and MCP-1 through a connective tissue growth factor independent pathway ...
TGF-beta(1) induced an increase in
IL-8 and MCP-1 ( both P < 0.05 ) compared with control levels ... In the CTGF silenced cells,
TGF-beta(1) stimulated
IL-8 and MCP-1 secretion was not altered compared with control cells ... These data suggest that
TGF-beta(1) induced
IL-8 and MCP-1 via CTGF independent pathway
Charalambous et al., Cancer Res 2005
(Brain Neoplasms...) :
Transforming growth factor-beta1 ( TGF-beta1 ), shown to down-regulate IL-8 production in BECs, does not
inhibit IL-8 production in TuBECs
Lu et al., Prostate 2006
(Prostatic Neoplasms) :
The purpose of this study was to investigate
TGF-beta1 regulated
IL-8 expression in prostate cancer cells ...
TGF-beta1 regulated
IL-8 expression was determined by real-time RT-PCR, enzyme linked immunoabsorbance assay ( ELISA ), nuclear run-on, and IL-8 promoter reporter assay ... The nuclear run-on and IL-8 luciferase reporter assays show that
TGF-beta1 activated
IL-8 gene transcription ...
TGF-beta1 signaling regulates IL-8 expression in prostate cancer cells and may
contribute to the overexpression of
IL-8 in human prostate cancer
Qi et al., American journal of physiology. Renal physiology 2006
:
We have recently demonstrated that
TGF-beta(1) induces
interleukin-8 (IL-8) , macrophage chemoattractant protein-1 ( MCP-1 ), and fibronectin production in renal proximal tubular ( HK-2 ) cells
Hosokawa et al., Clin Exp Immunol 2006
(Periodontitis) :
The
IL-8 and VEGF production induced by TWEAK was augmented synergistically by simultaneous
stimulation with
transforming growth factor (TGF)-beta1 or IL-1beta
Fong et al., J Bone Miner Res 2008
(Neoplasms) :
In addition,
TGF-beta1 also directly
induced IL-8 release in human cancer cells ... Activation of AP-1 and NF-kappaB DNA-protein binding and MAPKs after TGF-beta1 treatment was shown, and
TGF-beta1 induced
IL-8 promoter activity was inhibited by the specific inhibitors of MAPK cascades
Layh-Schmitt et al., Curr Opin Rheumatol 2008
(Spondylarthropathies) :
In mice,
transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages
promoting interleukin-17 production
Bekeredjian-Ding et al., Immunology 2009
(Head and Neck Neoplasms) :
Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and
transforming growth factor-beta ( TGF-beta )
increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha ( IFN-alpha ) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC
Zenkel et al., Am J Pathol 2010
(Exfoliation Syndrome...) :
IL-6 and IL-8 were significantly up-regulated by ciliary epithelial cells in response to hypoxia or oxidative stress in vitro, whereas IL-6, but not
IL-8 ,
induced the expression of
transforming growth factor-beta1 and elastic fiber proteins
Schuerer-Maly et al., Immunology 1994
:
IL-4, IL-10 and
transforming growth factor-beta ( TGF-beta ), which can down-regulate IL-8 production in macrophages,
had no effect on
IL-8 generation by our cell lines
Smith et al., J Immunol 1996
:
Transforming growth factor-beta 1 inhibits the production of
IL-8 and the transmigration of neutrophils through activated endothelium
Arici et al., J Clin Endocrinol Metab 1996
:
As part of an investigation of the regulation of the leukocyte population of endometrium/decidua, this study was conducted to evaluate further the
regulation of
interleukin-8 (IL-8) gene expression by
transforming growth factor-beta ( TGF beta )
Kumar et al., J Cell Physiol 1996
:
Induction of
interleukin-1 and interleukin-8 mRNAs and proteins by
TGF beta 1 in rat lung alveolar epithelial cells ...
Induction of interleukin-1 and
interleukin-8 mRNAs and proteins by
TGF beta 1 in rat lung alveolar epithelial cells ... In the current study, we sought to investigate whether
TGF beta 1 induced the expression of IL-1 alpha and
IL-8 in rat alveolar epithelial cells ... These results suggest that
TGF beta 1 may
regulate IL-1 alpha and
IL-8 expression in alveolar epithelial cells and contribute to polymorphonuclear leukocyte recruitment and lung injury in clinical states with increased TGF beta 1
Hedges et al., Cytokine 1996
:
IL-5, IL-12, IL-13 and
TGF-beta 1 additively enhanced the bacterially induced IL-6 secretion, but they did not
affect IL-8 secretion
Marth et al., Eur J Immunol 1997
:
Regulation of
transforming growth factor-beta production by
interleukin-12
Gerritsma et al., Kidney Int 1998
(Kidney Diseases) :
Transforming growth factor-beta 1 up-regulated
IL-8 production by an average of 4.17 +/- 1.0 fold
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by interleukin-10,
transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra