◀ Back to RAC1
DOCK2 — RAC1
Pathways - manually collected, often from reviews:
-
KEGG Fc gamma R-mediated phagocytosis:
DOCK2
→
RAC1/RAC2
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
Complex of DOCK2-ELMO1
→
RAC1/RAC2
(protein-protein, activation)
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GDP complex (RAC1)
→
DOCK2 (DOCK2)
(modification, collaborate)
Sanui et al., Blood 2003*, Kunisaki et al., J Cell Biol 2006*
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
DOCK2
→
RAC1
(direct_complex)
Janardhan et al., PLoS Biol 2004*
-
Reactome Reaction:
DOCK2
→
RAC1
(reaction)
Janardhan et al., PLoS Biol 2004*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
DOCK2
—
RAC1
(direct interaction, pull down)
Nishihara et al., Biochim Biophys Acta 1999*
-
IRef Dip Interaction:
Complex of DOCK2-RAC1-ELMO1
(anti tag coimmunoprecipitation)
Janardhan et al., PLoS Biol 2004*
-
IRef Hprd Interaction:
DOCK2
—
RAC1
(in vitro)
Nishihara et al., Biochim Biophys Acta 1999*
-
IRef Intact Interaction:
DOCK2
—
RAC1
(physical association, pull down)
Brugnera et al., Nat Cell Biol 2002
-
IRef Intact Interaction:
DOCK2
—
RAC1
(physical association, pull down)
Lu et al., Curr Biol 2005*
-
IRef Intact Interaction:
Complex of DOCK2-RAC1-ELMO1
(physical association, pull down)
Lu et al., Curr Biol 2005*
-
IRef Ophid Interaction:
DOCK2
—
RAC1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Sanui et al., Immunity 2003
:
We show here that
DOCK2 is
essential for TCR mediated
Rac activation and immunological synapse formation
Jiang et al., J Exp Med 2005
:
In addition, we found that
DOCK2 is
critical for CD28 mediated
Rac activation and is required for the full activation of alloreactive T cells
Kunisaki et al., J Cell Biol 2006
:
DOCK2 is a
Rac activator that regulates motility and polarity during neutrophil chemotaxis
Nishikimi et al., Science 2009
:
In neutrophils,
Rac activation is primarily
mediated by
DOCK2 , an atypical guanine nucleotide exchange factor
Namekata et al., Proc Natl Acad Sci U S A 2010
:
BDNF induces axonal sprouting through
Dock dependent
Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011
:
Multiple factors confer specific Cdc42 and
Rac protein
activation by
dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Ippagunta et al., Nat Immunol 2011
:
Thus, ASC shapes adaptive immunity independently of inflammasomes by modulating
Dock2 dependent
Rac activation and actin polymerization in DCs and lymphocytes
Kiyokawa et al., Genes Dev 1998
:
Activation of
Rac1 by a Crk SH3 binding protein,
DOCK180